Seroatlas · Human Serome Atlas

SLC46A2

Solute carrier family 46 member 2

Also known as: Ly110, S46A2_HUMAN, TSCOT

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BY10
Gene: SLC46A2
Ensembl: ENSG00000119457
Chromosome: 9
Canonical length: 475 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables cyclic-GMP-AMP transmembrane transporter activity. Involved in cyclic-GMP-AMP transmembrane import across plasma membrane and positive regulation of nucleotide-binding activity oligomerization domain containing 1 signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

475 residues, UniProt reviewed canonical sequence.

>Q9BY10|SLC46A2
     1  MSPEVTCPRR GHLPRFHPRT WVEPVVASSQ VAASLYDAGL LLVVKASYGT GGSSNHSASP
    61  SPRGALEDQQ QRAISNFYII YNLVVGLSPL LSAYGLGWLS DRYHRKISIC MSLLGFLLSR
   121  LGLLLKVLLD WPVEVLYGAA ALNGLFGGFS AFWSGVMALG SLGSSEGRRS VRLILIDLML
   181  GLAGFCGSMA SGHLFKQMAG HSGQGLILTA CSVSCASFAL LYSLLVLKVP ESVAKPSQEL
   241  PAVDTVSGTV GTYRTLDPDQ LDQQYAVGHP PSPGKAKPHK TTIALLFVGA IIYDLAVVGT
   301  VDVIPLFVLR EPLGWNQVQV GYGMAAGYTI FITSFLGVLV FSRCFRDTTM IMIGMVSFGS
   361  GALLLAFVKE TYMFYIARAV MLFALIPVTT IRSAMSKLIK GSSYGKVFVI LQLSLALTGV
   421  VTSTLYNKIY QLTMDMFVGS CFALSSFLSF LAIIPISIVA YKQVPLSPYG DIIEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC46A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

skin: 24 nTPM
cervix: 16 nTPM
thymus: 15 nTPM
lung: 9.9 nTPM
epididymis: 4.5 nTPM
endometrium: 2.9 nTPM

Single-cell type

esophageal apical cells: 41 nCPM
alveolar cells type 2: 35 nCPM
prostatic club cells: 30 nCPM
epididymal principal cells: 23 nCPM
endometrial ciliated cells: 22 nCPM
urothelial cells: 16 nCPM

Immune cell

classical monocyte: 25 nTPM
intermediate monocyte: 12 nTPM
non-classical monocyte: 10 nTPM
total PBMC: 6.6 nTPM
myeloid DC: 5.3 nTPM
neutrophil: 0.3 nTPM

Brain region

thalamus: 1.5 nTPM
cerebellum: 1.4 nTPM
cerebral cortex: 1.1 nTPM
hypothalamus: 0.9 nTPM
white matter: 0.9 nTPM
medulla oblongata: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: 0.15
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC46A2 as an antibody target. Whether an autoantibody or antibody against SLC46A2 could matter depends on whether native SLC46A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC46A2 is annotated at the cell surface, where native SLC46A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC46A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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