Seroatlas · Human Serome Atlas

SLC45A3

Solute carrier family 45 member 3

Also known as: IPCA-2, IPCA-6, IPCA-8, PCANAP2, PCANAP6, PCANAP8, prostein, S45A3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96JT2
Gene
SLC45A3
Ensembl
ENSG00000158715
Chromosome
1
Canonical length
553 aa
Protein class
Cancer-related genes, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable sucrose:proton symporter activity. Predicted to be involved in positive regulation of small molecule metabolic process; regulation of oligodendrocyte differentiation; and sucrose transport. Predicted to be located in plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

553 residues, UniProt reviewed canonical sequence.

>Q96JT2|SLC45A3
     1  MVQRLWVSRL LRHRKAQLLL VNLLTFGLEV CLAAGITYVP PLLLEVGVEE KFMTMVLGIG
    61  PVLGLVCVPL LGSASDHWRG RYGRRRPFIW ALSLGILLSL FLIPRAGWLA GLLCPDPRPL
   121  ELALLILGVG LLDFCGQVCF TPLEALLSDL FRDPDHCRQA YSVYAFMISL GGCLGYLLPA
   181  IDWDTSALAP YLGTQEECLF GLLTLIFLTC VAATLLVAEE AALGPTEPAE GLSAPSLSPH
   241  CCPCRARLAF RNLGALLPRL HQLCCRMPRT LRRLFVAELC SWMALMTFTL FYTDFVGEGL
   301  YQGVPRAEPG TEARRHYDEG VRMGSLGLFL QCAISLVFSL VMDRLVQRFG TRAVYLASVA
   361  AFPVAAGATC LSHSVAVVTA SAALTGFTFS ALQILPYTLA SLYHREKQVF LPKYRGDTGG
   421  ASSEDSLMTS FLPGPKPGAP FPNGHVGAGG SGLLPPPPAL CGASACDVSV RVVVGEPTEA
   481  RVVPGRGICL DLAILDSAFL LSQVAPSLFM GSIVQLSQSV TAYMVSAAGL GLVAIYFATQ
   541  VVFDKSDLAK YSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC45A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
288 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 288 nTPM
  • spinal cord: 27 nTPM
  • stomach: 16 nTPM
  • spleen: 11 nTPM
  • liver: 10 nTPM
  • midbrain: 10 nTPM

Single-cell type

  • prostatic glandular cells: 562 nCPM
  • mast cells: 80 nCPM
  • oligodendrocytes: 49 nCPM
  • platelets: 35 nCPM
  • epididymal efferent duct absorptive cells: 16 nCPM
  • foveolar cells: 14 nCPM

Immune cell

  • basophil: 41 nTPM
  • total PBMC: 0.4 nTPM
  • memory B-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • white matter: 92 nTPM
  • medulla oblongata: 54 nTPM
  • basal ganglia: 40 nTPM
  • pons: 40 nTPM
  • cerebellum: 38 nTPM
  • midbrain: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC45A3.

Disease | ImmuneIEDB

Conditions an epitope on SLC45A3 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0.01
gnomAD missense Z
1.58
DepMap mean gene effect
-0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC45A3 as an antibody target. Whether an autoantibody or antibody against SLC45A3 could matter depends on whether native SLC45A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC45A3 is annotated at the cell surface, where native SLC45A3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC45A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC45A3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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