Seroatlas · Human Serome Atlas

SLC45A1

Proton-associated sugar transporter A

Also known as: DNB5, S45A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2W3
Gene: SLC45A1
Ensembl: ENSG00000162426
Chromosome: 1
Canonical length: 748 aa
Protein class: Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene was isolated initially from a region on chromosome 1p that is frequently deleted in human neuroblastoma, although no causal relationship has since been demonstrated. The encoded protein belongs to the glycoside-pentoside-hexuronide cation symporter transporter family and may play a role in glucose uptake. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

748 residues, UniProt reviewed canonical sequence.

>Q9Y2W3|SLC45A1
     1  MIPAASSTPP GDALFPSVAP QDFWRSQVTG YSGSVTRHLS HRANNFKRHP KRRKCIRPSP
    61  PPPPNTPCPL ELVDFGDLHP QRSFRELLFN GCILFGIEFS YAMETAYVTP VLLQMGLPDQ
   121  LYSLVWFISP ILGFLLQPLL GAWSDRCTSR FGRRRPFILV LAIGALLGLS LLLNGRDIGI
   181  ALADVTGNHK WGLLLTVCGV VLMDFSADSA DNPSHAYMMD VCSPADQDRG LNIHALLAGL
   241  GGGFGYVVGG IHWDKTGFGR ALGGQLRVIY LFTAVTLSVT TVLTLVSIPE RPLRPPSEKR
   301  AAMKSPSLPL PPSPPVLPEE GPGDSLPSHT ATNFSSPISP PSPLTPKYGS FISRDSSLTG
   361  ISEFASSFGT ANIDSVLIDC FTGGHDSYLA IPGSVPRPPI SVSFPRAPDG FYRQDRGLLE
   421  GREGALTSGC DGDILRVGSL DTSKPRSSGI LKRPQTLAIP DAAGGGGPET SRRRNVTFSQ
   481  QVANILLNGV KYESELTGSS ERAEQPLSVG RLCSTICNMP KALRTLCVNH FLGWLSFEGM
   541  LLFYTDFMGE VVFQGDPKAP HTSEAYQKYN SGVTMGCWGM CIYAFSAAFY SAILEKLEEF
   601  LSVRTLYFIA YLAFGLGTGL ATLSRNLYVV LSLCITYGIL FSTLCTLPYS LLCDYYQSKK
   661  FAGSSADGTR RGMGVDISLL SCQYFLAQIL VSLVLGPLTS AVGSANGVMY FSSLVSFLGC
   721  LYSSLFVIYE IPPSDAADEE HRPLLLNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC45A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 10 nTPM
cerebral cortex: 8.4 nTPM
pituitary gland: 6.1 nTPM
blood vessel: 5.6 nTPM
basal ganglia: 5.5 nTPM
hypothalamus: 5.1 nTPM

Single-cell type

podocytes: 115 nCPM
retinal ganglion cells: 19 nCPM
other brain neurons: 17 nCPM
brain inhibitory neurons: 17 nCPM
bergmann glia: 16 nCPM
brain excitatory neurons: 15 nCPM

Immune cell

non-classical monocyte: 4 nTPM
MAIT T-cell: 0.8 nTPM
gdT-cell: 0.6 nTPM
intermediate monocyte: 0.6 nTPM
memory CD4 T-cell: 0.4 nTPM
memory CD8 T-cell: 0.4 nTPM

Brain region

pons: 25 nTPM
cerebral cortex: 23 nTPM
medulla oblongata: 22 nTPM
thalamus: 20 nTPM
hypothalamus: 19 nTPM
midbrain: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC45A1.

Disease | AllUniProt

Conditions SLC45A1 is implicated in, by any mechanism.

Intellectual developmental disorder with neuropsychiatric features (IDDNPF) MIM:617532

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 226 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Intellectual developmental disorder with neuropsychiatric features

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0
gnomAD missense Z: 1.47
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC45A1 as an antibody target. Whether an autoantibody or antibody against SLC45A1 could matter depends on whether native SLC45A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC45A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC45A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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