Seroatlas · Human Serome Atlas

SLC43A3

Equilibrative nucleobase transporter 1

Also known as: DKFZp762A227, Eeg1, FOAP-13, PRO1659, S43A3_HUMAN, SEEEG-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NBI5
Gene
SLC43A3
Ensembl
ENSG00000134802
Chromosome
11
Canonical length
491 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Vesicles,Plasma membrane

OverviewNCBI Gene

Enables adenine transmembrane transporter activity; guanine transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in hypoxanthine transport. Located in basolateral plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

491 residues, UniProt reviewed canonical sequence.

>Q8NBI5|SLC43A3
     1  MAGQGLPLHV ATLLTGLLEC LGFAGVLFGW PSLVFVFKNE DYFKDLCGPD AGPIGNATGQ
    61  ADCKAQDERF SLIFTLGSFM NNFMTFPTGY IFDRFKTTVA RLIAIFFYTT ATLIIAFTSA
   121  GSAVLLFLAM PMLTIGGILF LITNLQIGNL FGQHRSTIIT LYNGAFDSSS AVFLIIKLLY
   181  EKGISLRASF IFISVCSTWH VARTFLLMPR GHIPYPLPPN YSYGLCPGNG TTKEEKETAE
   241  HENRELQSKE FLSAKEETPG AGQKQELRSF WSYAFSRRFA WHLVWLSVIQ LWHYLFIGTL
   301  NSLLTNMAGG DMARVSTYTN AFAFTQFGVL CAPWNGLLMD RLKQKYQKEA RKTGSSTLAV
   361  ALCSTVPSLA LTSLLCLGFA LCASVPILPL QYLTFILQVI SRSFLYGSNA AFLTLAFPSE
   421  HFGKLFGLVM ALSAVVSLLQ FPIFTLIKGS LQNDPFYVNV MFMLAILLTF FHPFLVYREC
   481  RTWKESPSAI A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC43A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
135 nTPM

Expression across tissuesHPA

Tissue

  • liver: 135 nTPM
  • thyroid gland: 72 nTPM
  • adipose tissue: 59 nTPM
  • bone marrow: 55 nTPM
  • breast: 47 nTPM
  • lung: 45 nTPM

Single-cell type

  • erythrocyte progenitors: 11 nCPM
  • epicardial cells: 6.8 nCPM
  • mast cells: 6.8 nCPM
  • pdcs: 6.4 nCPM
  • myosatellite cells: 6.3 nCPM
  • monocytes: 5.8 nCPM

Immune cell

  • non-classical monocyte: 147 nTPM
  • intermediate monocyte: 127 nTPM
  • classical monocyte: 106 nTPM
  • plasmacytoid DC: 86 nTPM
  • myeloid DC: 86 nTPM
  • total PBMC: 61 nTPM

Brain region

  • thalamus: 20 nTPM
  • white matter: 14 nTPM
  • cerebral cortex: 12 nTPM
  • pons: 12 nTPM
  • hypothalamus: 11 nTPM
  • medulla oblongata: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
gnomAD missense Z
0.47
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC43A3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC43A3 as an antibody target. Whether an autoantibody or antibody against SLC43A3 could matter depends on whether native SLC43A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC43A3 is annotated at the cell surface, where native SLC43A3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC43A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC43A3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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