Seroatlas · Human Serome Atlas

SLC43A2

Large neutral amino acids transporter small subunit 4

Also known as: LAT4_HUMAN, MGC34680

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N370
Gene
SLC43A2
Ensembl
ENSG00000167703
Chromosome
17
Canonical length
569 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the L-amino acid transporter-3 or SLC43 family of transporters. The encoded protein mediates sodium-, chloride-, and pH-independent transport of L-isomers of neutral amino acids, including leucine, phenylalanine, valine and methionine. This protein may contribute to the transfer of amino acids across the placental membrane to the fetus. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

569 residues, UniProt reviewed canonical sequence.

>Q8N370|SLC43A2
     1  MAPTLATAHR RRWWMACTAV LENLLFSAVL LGWGSLLIML KSEGFYSYLC TEPENVTNGT
    61  VGGTAEPGHE EVSWMNGWLS CQAQDEMLNL AFTVGSFLLS AITLPLGIVM DKYGPRKLRL
   121  LGSACFAVSC LLIAYGASKP NALSVLIFIA LALNGFGGMC MTFTSLTLPN MFGDLRSTFI
   181  ALMIGSYASS AVTFPGIKLI YDAGVSFIVV LVVWAGCSGL VFLNCFFNWP LEPFPGPEDM
   241  DYSVKIKFSW LGFDHKITGK QFYKQVTTVG RRLSVGSSMR SAKEQVALQE GHKLCLSTVD
   301  LEVKCQPDAA VAPSFMHSVF SPILLLSLVT MCVTQLRLIF YMGAMNNILK FLVSGDQKTV
   361  GLYTSIFGVL QLLCLLTAPV IGYIMDWRLK ECEDASEEPE EKDANQGEKK KKKRDRQIQK
   421  ITNAMRAFAF TNLLLVGFGV TCLIPNLPLQ ILSFILHTIV RGFIHSAVGG LYAAVYPSTQ
   481  FGSLTGLQSL ISALFALLQQ PLFLAMMGPL QGDPLWVNVG LLLLSLLGFC LPLYLICYRR
   541  QLERQLQQRQ EDDKLFLKIN GSSNQEAFV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC43A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
55 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 55 nTPM
  • kidney: 37 nTPM
  • spleen: 29 nTPM
  • placenta: 21 nTPM
  • lung: 21 nTPM
  • cerebellum: 19 nTPM

Single-cell type

  • renal collecting duct intercalated cells: 395 nCPM
  • proximal tubule cells: 181 nCPM
  • loop of henle epithelial cells: 144 nCPM
  • renal connecting tubule cells: 121 nCPM
  • distal convoluted tubule cells: 108 nCPM
  • syncytiotrophoblasts: 102 nCPM

Immune cell

  • neutrophil: 16 nTPM
  • classical monocyte: 6.5 nTPM
  • eosinophil: 6.1 nTPM
  • non-classical monocyte: 5.2 nTPM
  • intermediate monocyte: 4.9 nTPM
  • myeloid DC: 3.4 nTPM

Brain region

  • medulla oblongata: 28 nTPM
  • pons: 26 nTPM
  • thalamus: 24 nTPM
  • cerebral cortex: 18 nTPM
  • cerebellum: 17 nTPM
  • hypothalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.57
gnomAD pLI
0.01
gnomAD missense Z
1.8
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC43A2 as an antibody target. Whether an autoantibody or antibody against SLC43A2 could matter depends on whether native SLC43A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC43A2 is annotated at the cell surface, where native SLC43A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC43A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC43A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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