Seroatlas · Human Serome Atlas

SLC43A1

Large neutral amino acids transporter small subunit 3

Also known as: LAT3_HUMAN, PB39, POV1, R00504

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75387
Gene
SLC43A1
Ensembl
ENSG00000149150
Chromosome
11
Canonical length
559 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus,Vesicles,Plasma membrane

OverviewNCBI Gene

SLC43A1 belongs to the system L family of plasma membrane carrier proteins that transports large neutral amino acids (Babu et al., 2003 [PubMed 12930836]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

559 residues, UniProt reviewed canonical sequence.

>O75387|SLC43A1
     1  MAPTLQQAYR RRWWMACTAV LENLFFSAVL LGWGSLLIIL KNEGFYSSTC PAESSTNTTQ
    61  DEQRRWPGCD QQDEMLNLGF TIGSFVLSAT TLPLGILMDR FGPRPVRLVG SACFTASCTL
   121  MALASRDVEA LSPLIFLALS LNGFGGICLT FTSLTLPNMF GNLRSTLMAL MIGSYASSAI
   181  TFPGIKLIYD AGVAFVVIMF TWSGLACLIF LNCTLNWPIE AFPAPEEVNY TKKIKLSGLA
   241  LDHKVTGDLF YTHVTTMGQR LSQKAPSLED GSDAFMSPQD VRGTSENLPE RSVPLRKSLC
   301  SPTFLWSLLT MGMTQLRIIF YMAAVNKMLE YLVTGGQEHE TNEQQQKVAE TVGFYSSVFG
   361  AMQLLCLLTC PLIGYIMDWR IKDCVDAPTQ GTVLGDARDG VATKSIRPRY CKIQKLTNAI
   421  SAFTLTNLLL VGFGITCLIN NLHLQFVTFV LHTIVRGFFH SACGSLYAAV FPSNHFGTLT
   481  GLQSLISAVF ALLQQPLFMA MVGPLKGEPF WVNLGLLLFS LLGFLLPSYL FYYRARLQQE
   541  YAANGMGPLK VLSGSEVTA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC43A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
220 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 220 nTPM
  • liver: 122 nTPM
  • bone marrow: 34 nTPM
  • stomach: 29 nTPM
  • ovary: 20 nTPM
  • skin: 18 nTPM

Single-cell type

  • hepatocytes: 168 nCPM
  • pancreatic acinar cells: 97 nCPM
  • erythrocyte progenitors: 79 nCPM
  • cholangiocytes: 46 nCPM
  • gastric chief cells: 44 nCPM
  • distal convoluted tubule cells: 40 nCPM

Immune cell

  • basophil: 11 nTPM
  • gdT-cell: 11 nTPM
  • T-reg: 9.5 nTPM
  • MAIT T-cell: 9.2 nTPM
  • myeloid DC: 8.4 nTPM
  • memory CD8 T-cell: 7.7 nTPM

Brain region

  • cerebral cortex: 7.3 nTPM
  • white matter: 5.3 nTPM
  • pons: 5.1 nTPM
  • amygdala: 4.7 nTPM
  • hippocampal formation: 4.4 nTPM
  • thalamus: 4.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0
gnomAD missense Z
1.09
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC43A1 as an antibody target. Whether an autoantibody or antibody against SLC43A1 could matter depends on whether native SLC43A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC43A1 is annotated at the cell surface, where native SLC43A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC43A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC43A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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