Seroatlas · Human Serome Atlas

SLC40A1

Ferroportin

Also known as: FPN1, HFE4, IREG1, MTP1, S40A1_HUMAN, SLC11A3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NP59
Gene
SLC40A1
Ensembl
ENSG00000138449
Chromosome
2
Canonical length
571 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

571 residues, UniProt reviewed canonical sequence.

>Q9NP59|SLC40A1
     1  MTRAGDHNRQ RGCCGSLADY LTSAKFLLYL GHSLSTWGDR MWHFAVSVFL VELYGNSLLL
    61  TAVYGLVVAG SVLVLGAIIG DWVDKNARLK VAQTSLVVQN VSVILCGIIL MMVFLHKHEL
   121  LTMYHGWVLT SCYILIITIA NIANLASTAT AITIQRDWIV VVAGEDRSKL ANMNATIRRI
   181  DQLTNILAPM AVGQIMTFGS PVIGCGFISG WNLVSMCVEY VLLWKVYQKT PALAVKAGLK
   241  EEETELKQLN LHKDTEPKPL EGTHLMGVKD SNIHELEHEQ EPTCASQMAE PFRTFRDGWV
   301  SYYNQPVFLA GMGLAFLYMT VLGFDCITTG YAYTQGLSGS ILSILMGASA ITGIMGTVAF
   361  TWLRRKCGLV RTGLISGLAQ LSCLILCVIS VFMPGSPLDL SVSPFEDIRS RFIQGESITP
   421  TKIPEITTEI YMSNGSNSAN IVPETSPESV PIISVSLLFA GVIAARIGLW SFDLTVTQLL
   481  QENVIESERG IINGVQNSMN YLLDLLHFIM VILAPNPEAF GLLVLISVSF VAMGHIMYFR
   541  FAQNTLGNKL FACGPDAKEV RKENQANTSV V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC40A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
347 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 347 nTPM
  • adrenal gland: 322 nTPM
  • duodenum: 272 nTPM
  • ovary: 238 nTPM
  • liver: 235 nTPM
  • placenta: 235 nTPM

Single-cell type

  • kupffer cells: 3,945 nCPM
  • syncytiotrophoblasts: 3,638 nCPM
  • platelets: 987 nCPM
  • cytotrophoblasts: 591 nCPM
  • megakaryocyte-erythroid progenitors: 469 nCPM
  • fallopian secretory cells: 410 nCPM

Immune cell

  • neutrophil: 328 nTPM
  • eosinophil: 173 nTPM
  • basophil: 130 nTPM
  • myeloid DC: 116 nTPM
  • total PBMC: 106 nTPM
  • classical monocyte: 102 nTPM

Brain region

  • midbrain: 27 nTPM
  • spinal cord: 26 nTPM
  • medulla oblongata: 25 nTPM
  • thalamus: 22 nTPM
  • hypothalamus: 18 nTPM
  • basal ganglia: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC40A1.

Disease | AllUniProt

Conditions SLC40A1 is implicated in, by any mechanism.

Disease | GeneticClinVar

41 pathogenic / likely-pathogenic of 335 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hemochromatosis type 4
  • SLC40A1-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.99
gnomAD missense Z
1.92
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC40A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC40A1 as an antibody target. Whether an autoantibody or antibody against SLC40A1 could matter depends on whether native SLC40A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC40A1 is annotated at the cell surface, where native SLC40A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC40A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC40A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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