Seroatlas · Human Serome Atlas

SLC39A9

Zinc transporter ZIP9

Also known as: FLJ11274, S39A9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NUM3
Gene: SLC39A9
Ensembl: ENSG00000029364
Chromosome: 14
Canonical length: 307 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

Enables G protein-coupled receptor activity; androgen binding activity; and zinc efflux transmembrane transporter activity. Involved in intracellular zinc ion homeostasis; regulation of vascular endothelial cell proliferation; and zinc ion transmembrane transport. Located in several cellular components, including mitochondrial membrane; perinuclear region of cytoplasm; and trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>Q9NUM3|SLC39A9
     1  MDDFISISLL SLAMLVGCYV AGIIPLAVNF SEERLKLVTV LGAGLLCGTA LAVIVPEGVH
    61  ALYEDILEGK HHQASETHNV IASDKAAEKS VVHEHEHSHD HTQLHAYIGV SLVLGFVFML
   121  LVDQIGNSHV HSTDDPEAAR SSNSKITTTL GLVVHAAADG VALGAAASTS QTSVQLIVFV
   181  AIMLHKAPAA FGLVSFLMHA GLERNRIRKH LLVFALAAPV MSMVTYLGLS KSSKEALSEV
   241  NATGVAMLFS AGTFLYVATV HVLPEVGGIG HSHKPDATGG RGLSRLEVAA LVLGCLIPLI
   301  LSVGHQH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC39A9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

liver: 41 nTPM
salivary gland: 32 nTPM
kidney: 28 nTPM
pancreas: 27 nTPM
parathyroid gland: 25 nTPM
epididymis: 24 nTPM

Single-cell type

hepatocytes: 91 nCPM
somatotrophs: 91 nCPM
salivary acinar cells: 88 nCPM
choroid plexus epithelial cells: 84 nCPM
lactotrophs: 83 nCPM
parietal cells: 81 nCPM

Immune cell

myeloid DC: 11 nTPM
basophil: 11 nTPM
classical monocyte: 10 nTPM
intermediate monocyte: 9.7 nTPM
eosinophil: 9.4 nTPM
non-classical monocyte: 9.4 nTPM

Brain region

choroid plexus: 33 nTPM
white matter: 30 nTPM
hypothalamus: 28 nTPM
spinal cord: 28 nTPM
thalamus: 28 nTPM
cerebellum: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.73
gnomAD missense Z: 1.97
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

bicellular tight junction assembly
intracellular zinc ion homeostasis
regulation of vascular endothelial cell proliferation
zinc ion transmembrane transport
regulation of cellular response to testosterone stimulus

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC39A9 as an antibody target. Whether an autoantibody or antibody against SLC39A9 could matter depends on whether native SLC39A9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC39A9 is annotated at the cell surface, where native SLC39A9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC39A9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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