Seroatlas · Human Serome Atlas

SLC39A8

Metal cation symporter ZIP8

Also known as: BIGM103, S39A8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9C0K1
Gene
SLC39A8
Ensembl
ENSG00000138821
Chromosome
4
Canonical length
460 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

460 residues, UniProt reviewed canonical sequence.

>Q9C0K1|SLC39A8
     1  MAPGRAVAGL LLLAAAGLGG VAEGPGLAFS EDVLSVFGAN LSLSAAQLQH LLEQMGAASR
    61  VGVPEPGQLH FNQCLTAEEI FSLHGFSNAT QITSSKFSVI CPAVLQQLNF HPCEDRPKHK
   121  TRPSHSEVWG YGFLSVTIIN LASLLGLILT PLIKKSYFPK ILTFFVGLAI GTLFSNAIFQ
   181  LIPEAFGFDP KVDSYVEKAV AVFGGFYLLF FFERMLKMLL KTYGQNGHTH FGNDNFGPQE
   241  KTHQPKALPA INGVTCYANP AVTEANGHIH FDNVSVVSLQ DGKKEPSSCT CLKGPKLSEI
   301  GTIAWMITLC DALHNFIDGL AIGASCTLSL LQGLSTSIAI LCEEFPHELG DFVILLNAGM
   361  STRQALLFNF LSACSCYVGL AFGILVGNNF APNIIFALAG GMFLYISLAD MFPEMNDMLR
   421  EKVTGRKTDF TFFMIQNAGM LTGFTAILLI TLYAGEIELE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC39A8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
59 nTPM

Expression across tissuesHPA

Tissue

  • lung: 59 nTPM
  • salivary gland: 45 nTPM
  • pancreas: 24 nTPM
  • adipose tissue: 23 nTPM
  • cervix: 16 nTPM
  • appendix: 15 nTPM

Single-cell type

  • epicardial cells: 1,954 nCPM
  • alveolar cells type 1: 1,203 nCPM
  • alveolar cells type 2: 900 nCPM
  • mesothelial cells: 511 nCPM
  • transitional alveolar cells: 421 nCPM
  • salivary acinar cells: 369 nCPM

Immune cell

  • memory CD4 T-cell: 10 nTPM
  • NK-cell: 9.6 nTPM
  • MAIT T-cell: 9.3 nTPM
  • memory CD8 T-cell: 8.7 nTPM
  • naive CD4 T-cell: 7.9 nTPM
  • gdT-cell: 5.4 nTPM

Brain region

  • medulla oblongata: 14 nTPM
  • spinal cord: 12 nTPM
  • thalamus: 10 nTPM
  • pons: 10 nTPM
  • hypothalamus: 9.3 nTPM
  • white matter: 8.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC39A8.

Disease | AllUniProt

Conditions SLC39A8 is implicated in, by any mechanism.

  • Congenital disorder of glycosylation 2N (CDG2N) MIM:616721

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 263 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • SLC39A8-CDG

Disease | ImmuneIEDB

Conditions an epitope on SLC39A8 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.67
gnomAD missense Z
1.1
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC39A8 as an antibody target. Whether an autoantibody or antibody against SLC39A8 could matter depends on whether native SLC39A8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC39A8 is annotated at the cell surface, where native SLC39A8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC39A8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC39A8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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