Seroatlas · Human Serome Atlas

SLC39A5

Zinc transporter ZIP5

Also known as: S39A5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZMH5
Gene
SLC39A5
Ensembl
ENSG00000139540
Chromosome
12
Canonical length
540 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene belongs to the ZIP family of zinc transporters that transport zinc into cells from outside, and play a crucial role in controlling intracellular zinc levels. Zinc is an essential cofactor for many enzymes and proteins involved in gene transcription, growth, development and differentiation. Mutations in this gene have been associated with autosomal dominant high myopia (MYP24). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

540 residues, UniProt reviewed canonical sequence.

>Q6ZMH5|SLC39A5
     1  MMGSPVSHLL AGFCVWVVLG WVGGSVPNLG PAEQEQNHYL AQLFGLYGEN GTLTAGGLAR
    61  LLHSLGLGRV QGLRLGQHGP LTGRAASPAA DNSTHRPQNP ELSVDVWAGM PLGPSGWGDL
   121  EESKAPHLPR GPAPSGLDLL HRLLLLDHSL ADHLNEDCLN GSQLLVNFGL SPAAPLTPRQ
   181  FALLCPALLY QIDSRVCIGA PAPAPPGDLL SALLQSALAV LLLSLPSPLS LLLLRLLGPR
   241  LLRPLLGFLG ALAVGTLCGD ALLHLLPHAQ EGRHAGPGGL PEKDLGPGLS VLGGLFLLFV
   301  LENMLGLLRH RGLRPRCCRR KRRNLETRNL DPENGSGMAL QPLQAAPEPG AQGQREKNSQ
   361  HPPALAPPGH QGHSHGHQGG TDITWMVLLG DGLHNLTDGL AIGAAFSDGF SSGLSTTLAV
   421  FCHELPHELG DFAMLLQSGL SFRRLLLLSL VSGALGLGGA VLGVGLSLGP VPLTPWVFGV
   481  TAGVFLYVAL VDMLPALLRP PEPLPTPHVL LQGLGLLLGG GLMLAITLLE ERLLPVTTEG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC39A5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
292 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 292 nTPM
  • duodenum: 223 nTPM
  • small intestine: 206 nTPM
  • liver: 166 nTPM
  • kidney: 103 nTPM
  • colon: 69 nTPM

Single-cell type

  • enterocytes: 745 nCPM
  • colonocytes: 184 nCPM
  • hepatocytes: 184 nCPM
  • enteric transient amplifying cells: 173 nCPM
  • paneth cells: 159 nCPM
  • pancreatic acinar cells: 142 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 1.1 nTPM
  • cerebral cortex: 0.9 nTPM
  • amygdala: 0.6 nTPM
  • medulla oblongata: 0.6 nTPM
  • basal ganglia: 0.5 nTPM
  • choroid plexus: 0.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC39A5.

Disease | AllUniProt

Conditions SLC39A5 is implicated in, by any mechanism.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 130 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Myopia 24, autosomal dominant

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.2
gnomAD pLI
0
gnomAD missense Z
0.24
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC39A5 as an antibody target. Whether an autoantibody or antibody against SLC39A5 could matter depends on whether native SLC39A5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC39A5 is annotated at the cell surface, where native SLC39A5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC39A5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC39A5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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