Seroatlas · Human Serome Atlas

SLC39A3

Zinc transporter ZIP3

Also known as: S39A3_HUMAN, ZIP3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRY0
Gene: SLC39A3
Ensembl: ENSG00000141873
Chromosome: 19
Canonical length: 314 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in zinc ion transmembrane transport. Predicted to act upstream of or within several processes, including T cell homeostasis; chordate embryonic development; and zinc ion transport. Predicted to be located in hippocampal mossy fiber to CA3 synapse. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

314 residues, UniProt reviewed canonical sequence.

>Q9BRY0|SLC39A3
     1  MVKLLVAKIL CMVGVFFFML LGSLLPVKII ETDFEKAHRS KKILSLCNTF GGGVFLATCF
    61  NALLPAVREK LQKVLSLGHI STDYPLAETI LLLGFFMTVF LEQLILTFRK EKPSFIDLET
   121  FNAGSDVGSD SEYESPFMGG ARGHALYVEP HGHGPSLSVQ GLSRASPVRL LSLAFALSAH
   181  SVFEGLALGL QEEGEKVVSL FVGVAVHETL VAVALGISMA RSAMPLRDAA KLAVTVSAMI
   241  PLGIGLGLGI ESAQGVPGSV ASVLLQGLAG GTFLFITFLE ILAKELEEKS DRLLKVLFLV
   301  LGYTVLAGMV FLKW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC39A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 97 nTPM

Expression across tissuesHPA

Tissue

testis: 97 nTPM
bone marrow: 44 nTPM
liver: 33 nTPM
parathyroid gland: 33 nTPM
cerebral cortex: 31 nTPM
epididymis: 29 nTPM

Single-cell type

late spermatids: 11 nCPM
hepatic stellate cells: 6.5 nCPM
late primary spermatocytes: 5.2 nCPM
megakaryocyte-erythroid progenitors: 4.3 nCPM
retinal pigment epithelial cells: 4.3 nCPM
early spermatids: 3.2 nCPM

Immune cell

plasmacytoid DC: 84 nTPM
eosinophil: 68 nTPM
naive B-cell: 54 nTPM
memory B-cell: 54 nTPM
myeloid DC: 49 nTPM
basophil: 41 nTPM

Brain region

hippocampal formation: 44 nTPM
cerebral cortex: 44 nTPM
medulla oblongata: 37 nTPM
thalamus: 37 nTPM
amygdala: 34 nTPM
hypothalamus: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0.12
gnomAD missense Z: 0.67
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC39A3 as an antibody target. Whether an autoantibody or antibody against SLC39A3 could matter depends on whether native SLC39A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC39A3 is annotated at the cell surface, where native SLC39A3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC39A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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