Seroatlas · Human Serome Atlas

SLC39A2

Zinc transporter ZIP2

Also known as: S39A2_HUMAN, ZIP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NP94
Gene: SLC39A2
Ensembl: ENSG00000165794
Chromosome: 14
Canonical length: 309 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location: Plasma membrane,Cytoplasmic bodies

OverviewNCBI Gene

This gene encodes a member of the ZIP family of metal ion transporters. The encoded protein functions as a zinc transporter. Mutations in this gene may be associated with susceptibility to carotid artery disease. Multiple transcript variants have been described. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q9NP94|SLC39A2
     1  MEQLLGIKLG CLFALLALTL GCGLTPICFK WFQIDAARGH HRLVLRLLGC ISAGVFLGAG
    61  FMHMTAEALE EIESQIQKFM VQNRSASERN SSGDADSAHM EYPYGELIIS LGFFFVFFLE
   121  SLALQCCPGA AGGSTVQDEE WGGAHIFELH SHGHLPSPSK GPLRALVLLL SLSFHSVFEG
   181  LAVGLQPTVA ATVQLCLAVL AHKGLVVFGV GMRLVHLGTS SRWAVFSILL LALMSPLGLA
   241  VGLAVTGGDS EGGRGLAQAV LEGVAAGTFL YVTFLEILPR ELASPEAPLA KWSCVAAGFA
   301  FMAFIALWA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC39A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

skin: 36 nTPM
seminal vesicle: 31 nTPM
esophagus: 18 nTPM
vagina: 14 nTPM
cervix: 12 nTPM
prostate: 11 nTPM

Single-cell type

esophageal suprabasal cells: 59 nCPM
esophageal apical cells: 34 nCPM
müller glia: 18 nCPM
suprabasal keratinocytes: 17 nCPM
esophageal basal cells: 15 nCPM
ocular epithelial cells: 13 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.5 nTPM
cerebral cortex: 0.4 nTPM
cerebellum: 0.3 nTPM
basal ganglia: 0.2 nTPM
hippocampal formation: 0.2 nTPM
medulla oblongata: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: -0.47
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC39A2 as an antibody target. Whether an autoantibody or antibody against SLC39A2 could matter depends on whether native SLC39A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC39A2 is annotated at the cell surface, where native SLC39A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC39A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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