Seroatlas · Human Serome Atlas

SLC39A14

Metal cation symporter ZIP14

Also known as: KIAA0062, NET34, S39AE_HUMAN, ZIP14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15043
Gene
SLC39A14
Ensembl
ENSG00000104635
Chromosome
8
Canonical length
492 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Endoplasmic reticulum,Golgi apparatus,Plasma membrane
Quaternary structure
Homotrimer

OverviewNCBI Gene

This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine-rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are associated with neurodegeneration with brain iron accumulation and early-onset parkinsonism-dystonia with hypermanganesemia. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

492 residues, UniProt reviewed canonical sequence.

>Q15043|SLC39A14
     1  MKLLLLHPAF QSCLLLTLLG LWRTTPEAHA SSLGAPAISA ASFLQDLIHR YGEGDSLTLQ
    61  QLKALLNHLD VGVGRGNVTQ HVQGHRNLST CFSSGDLFTA HNFSEQSRIG SSELQEFCPT
   121  ILQQLDSRAC TSENQENEEN EQTEEGRPSA VEVWGYGLLC VTVISLCSLL GASVVPFMKK
   181  TFYKRLLLYF IALAIGTLYS NALFQLIPEA FGFNPLEDYY VSKSAVVFGG FYLFFFTEKI
   241  LKILLKQKNE HHHGHSHYAS ESLPSKKDQE EGVMEKLQNG DLDHMIPQHC SSELDGKAPM
   301  VDEKVIVGSL SVQDLQASQS ACYWLKGVRY SDIGTLAWMI TLSDGLHNFI DGLAIGASFT
   361  VSVFQGISTS VAILCEEFPH ELGDFVILLN AGMSIQQALF FNFLSACCCY LGLAFGILAG
   421  SHFSANWIFA LAGGMFLYIS LADMFPEMNE VCQEDERKGS ILIPFIIQNL GLLTGFTIMV
   481  VLTMYSGQIQ IG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC39A14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
516 nTPM

Expression across tissuesHPA

Tissue

  • liver: 516 nTPM
  • pancreas: 236 nTPM
  • duodenum: 134 nTPM
  • thyroid gland: 82 nTPM
  • small intestine: 80 nTPM
  • stomach: 74 nTPM

Single-cell type

  • pancreatic acinar cells: 748 nCPM
  • hepatocytes: 678 nCPM
  • endometrial luminal cells: 588 nCPM
  • pancreatic duct cells: 242 nCPM
  • salivary myoepithelial cells: 220 nCPM
  • endometrial glandular cells: 193 nCPM

Immune cell

  • MAIT T-cell: 7.2 nTPM
  • gdT-cell: 6.7 nTPM
  • naive CD8 T-cell: 6 nTPM
  • memory CD8 T-cell: 5 nTPM
  • naive CD4 T-cell: 4.3 nTPM
  • memory B-cell: 4.1 nTPM

Brain region

  • medulla oblongata: 100 nTPM
  • choroid plexus: 94 nTPM
  • midbrain: 74 nTPM
  • thalamus: 65 nTPM
  • pons: 65 nTPM
  • hypothalamus: 58 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC39A14.

Disease | AllUniProt

Conditions SLC39A14 is implicated in, by any mechanism.

  • Hypermanganesemia with dystonia 2 (HMNDYT2) MIM:617013
  • Hyperostosis cranialis interna (HCIN) MIM:144755

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 286 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hypermanganesemia with dystonia 2
  • Hyperostosis cranialis interna

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.15
gnomAD missense Z
1.92
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC39A14 as an antibody target. Whether an autoantibody or antibody against SLC39A14 could matter depends on whether native SLC39A14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC39A14 is annotated at the cell surface, where native SLC39A14 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC39A14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC39A14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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