Seroatlas · Human Serome Atlas

SLC39A13

Zinc transporter ZIP13

Also known as: FLJ25785, S39AD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96H72
Gene
SLC39A13
Ensembl
ENSG00000165915
Chromosome
11
Canonical length
371 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the LIV-1 subfamily of the ZIP transporter family. The encoded transmembrane protein functions as a zinc transporter. Mutations in this gene have been associated with the spondylocheiro dysplastic form of Ehlers-Danlos syndrome. Alternate transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

371 residues, UniProt reviewed canonical sequence.

>Q96H72|SLC39A13
     1  MPGCPCPGCG MAGPRLLFLT ALALELLERA GGSQPALRSR GTATACRLDN KESESWGALL
    61  SGERLDTWIC SLLGSLMVGL SGVFPLLVIP LEMGTMLRSE AGAWRLKQLL SFALGGLLGN
   121  VFLHLLPEAW AYTCSASPGG EGQSLQQQQQ LGLWVIAGIL TFLALEKMFL DSKEEGTSQA
   181  PNKDPTAAAA ALNGGHCLAQ PAAEPGLGAV VRSIKVSGYL NLLANTIDNF THGLAVAASF
   241  LVSKKIGLLT TMAILLHEIP HEVGDFAILL RAGFDRWSAA KLQLSTALGG LLGAGFAICT
   301  QSPKGVVGCS PAAEETAAWV LPFTSGGFLY IALVNVLPDL LEEEDPWRSL QQLLLLCAGI
   361  VVMVLFSLFV D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC39A13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
8
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
85 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 85 nTPM
  • blood vessel: 81 nTPM
  • endometrium: 69 nTPM
  • testis: 69 nTPM
  • cerebellum: 59 nTPM
  • lung: 57 nTPM

Single-cell type

  • late spermatids: 1,677 nCPM
  • early spermatids: 348 nCPM
  • late primary spermatocytes: 82 nCPM
  • alveolar cells type 1: 44 nCPM
  • peritubular myoid cells: 40 nCPM
  • decidual stromal cells: 40 nCPM

Immune cell

  • non-classical monocyte: 15 nTPM
  • intermediate monocyte: 13 nTPM
  • gdT-cell: 12 nTPM
  • memory CD8 T-cell: 8.9 nTPM
  • MAIT T-cell: 8.5 nTPM
  • memory CD4 T-cell: 8.2 nTPM

Brain region

  • thalamus: 55 nTPM
  • medulla oblongata: 50 nTPM
  • basal ganglia: 46 nTPM
  • pons: 45 nTPM
  • cerebellum: 45 nTPM
  • choroid plexus: 44 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC39A13.

Disease | AllUniProt

Conditions SLC39A13 is implicated in, by any mechanism.

  • Ehlers-Danlos syndrome, spondylodysplastic type, 3 (EDSSPD3) MIM:612350

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 417 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Ehlers-Danlos syndrome, spondylocheirodysplastic type

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0
gnomAD missense Z
1.26
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC39A13 as an antibody target. Whether an autoantibody or antibody against SLC39A13 could matter depends on whether native SLC39A13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC39A13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC39A13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC39A13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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