Seroatlas · Human Serome Atlas

SLC39A11

Zinc transporter ZIP11

Also known as: C17orf26, S39AB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N1S5
Gene: SLC39A11
Ensembl: ENSG00000133195
Chromosome: 17
Canonical length: 342 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable copper ion transmembrane transporter activity and zinc ion transmembrane transporter activity. Predicted to be involved in zinc ion transmembrane transport. Predicted to be located in Golgi apparatus; nucleus; and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

342 residues, UniProt reviewed canonical sequence.

>Q8N1S5|SLC39A11
     1  MLQGHSSVFQ ALLGTFFTWG MTAAGAALVF VFSSGQRRIL DGSLGFAAGV MLAASYWSLL
    61  APAVEMATSS GGFGAFAFFP VAVGFTLGAA FVYLADLLMP HLGAAEDPQT TLALNFGSTL
   121  MKKKSDPEGP ALLFPESELS IRIGRAGLLS DKSENGEAYQ RKKAAATGLP EGPAVPVPSR
   181  GNLAQPGGSS WRRIALLILA ITIHNVPEGL AVGVGFGAIE KTASATFESA RNLAIGIGIQ
   241  NFPEGLAVSL PLRGAGFSTW RAFWYGQLSG MVEPLAGVFG AFAVVLAEPI LPYALAFAAG
   301  AMVYVVMDDI IPEAQISGNG KLASWASILG FVVMMSLDVG LG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC39A11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

stomach: 46 nTPM
liver: 37 nTPM
thyroid gland: 34 nTPM
salivary gland: 29 nTPM
pancreas: 28 nTPM
colon: 23 nTPM

Single-cell type

neutrophil progenitors: 637 nCPM
astrocytes: 571 nCPM
bergmann glia: 475 nCPM
oligodendrocytes: 456 nCPM
proximal tubule cells: 373 nCPM
mast cells: 359 nCPM

Immune cell

intermediate monocyte: 41 nTPM
classical monocyte: 40 nTPM
myeloid DC: 38 nTPM
non-classical monocyte: 33 nTPM
plasmacytoid DC: 27 nTPM
eosinophil: 26 nTPM

Brain region

white matter: 80 nTPM
basal ganglia: 66 nTPM
medulla oblongata: 64 nTPM
thalamus: 61 nTPM
midbrain: 58 nTPM
cerebellum: 56 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC39A11 as an antibody target. Whether an autoantibody or antibody against SLC39A11 could matter depends on whether native SLC39A11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC39A11 is annotated at the cell surface, where native SLC39A11 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC39A11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...