Seroatlas · Human Serome Atlas

SLC37A4

Glucose-6-phosphate exchanger SLC37A4

Also known as: G6PT1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43826
Gene
SLC37A4
Canonical length
429 aa
Protein class
Human disease related genes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for SLC37A4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

429 residues, UniProt reviewed canonical sequence.

>O43826|SLC37A4
     1  MAAQGYGYYR TVIFSAMFGG YSLYYFNRKT FSFVMPSLVE EIPLDKDDLG FITSSQSAAY
    61  AISKFVSGVL SDQMSARWLF SSGLLLVGLV NIFFAWSSTV PVFAALWFLN GLAQGLGWPP
   121  CGKVLRKWFE PSQFGTWWAI LSTSMNLAGG LGPILATILA QSYSWRSTLA LSGALCVVVS
   181  FLCLLLIHNE PADVGLRNLD PMPSEGKKGS LKEESTLQEL LLSPYLWVLS TGYLVVFGVK
   241  TCCTDWGQFF LIQEKGQSAL VGSSYMSALE VGGLVGSIAA GYLSDRAMAK AGLSNYGNPR
   301  HGLLLFMMAG MTVSMYLFRV TVTSDSPKLW ILVLGAVFGF SSYGPIALFG VIANESAPPN
   361  LCGTSHAIVG LMANVGGFLA GLPFSTIAKH YSWSTAFWVA EVICAASTAA FFLLRNIRTK
   421  MGRVSKKAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC37A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
9
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
134 nTPM

Expression across tissuesHPA

Tissue

  • liver: 134 nTPM
  • kidney: 48 nTPM
  • pancreas: 38 nTPM
  • duodenum: 34 nTPM
  • small intestine: 26 nTPM
  • epididymis: 19 nTPM

Single-cell type

  • proximal tubule cells: 30 nCPM
  • podocytes: 15 nCPM
  • microglia: 13 nCPM
  • loop of henle epithelial cells: 7.5 nCPM
  • astrocytes: 7.1 nCPM
  • renal collecting duct intercalated cells: 6.6 nCPM

Immune cell

  • memory CD8 T-cell: 1.7 nTPM
  • intermediate monocyte: 1.6 nTPM
  • gdT-cell: 1.4 nTPM
  • eosinophil: 1.3 nTPM
  • MAIT T-cell: 1.3 nTPM
  • naive CD8 T-cell: 1.1 nTPM

Brain region

  • medulla oblongata: 1.1 nTPM
  • hypothalamus: 0.8 nTPM
  • spinal cord: 0.8 nTPM
  • choroid plexus: 0.7 nTPM
  • white matter: 0.7 nTPM
  • cerebral cortex: 0.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC37A4.

Disease | AllUniProt

Conditions SLC37A4 is implicated in, by any mechanism.

Disease | GeneticClinVar

182 pathogenic / likely-pathogenic of 1,140 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.88
gnomAD pLI
0
gnomAD missense Z
0

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC37A4 as an antibody target. Whether an autoantibody or antibody against SLC37A4 could matter depends on whether native SLC37A4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC37A4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC37A4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC37A4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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