Seroatlas · Human Serome Atlas

SLC37A2

Glucose-6-phosphate exchanger SLC37A2

Also known as: FLJ00171, G6PT3_HUMAN, SPX2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TED4
Gene: SLC37A2
Ensembl: ENSG00000134955
Chromosome: 11
Canonical length: 501 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables glucose 6-phosphate:phosphate antiporter activity. Involved in glucose-6-phosphate transport and phosphate ion transmembrane transport. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

501 residues, UniProt reviewed canonical sequence.

>Q8TED4|SLC37A2
     1  MRSSLAPGVW FFRAFSRDSW FRGLILLLTF LIYACYHMSR KPISIVKSRL HQNCSEQIKP
    61  INDTHSLNDT MWCSWAPFDK DNYKELLGGV DNAFLIAYAI GMFISGVFGE RLPLRYYLSA
   121  GMLLSGLFTS LFGLGYFWNI HELWYFVVIQ VCNGLVQTTG WPSVVTCVGN WFGKGKRGFI
   181  MGIWNSHTSV GNILGSLIAG IWVNGQWGLS FIVPGIITAV MGVITFLFLI EHPEDVDCAP
   241  PQHHGEPAEN QDNPEDPGNS PCSIRESGLE TVAKCSKGPC EEPAAISFFG ALRIPGVVEF
   301  SLCLLFAKLV SYTFLYWLPL YIANVAHFSA KEAGDLSTLF DVGGIIGGIV AGLVSDYTNG
   361  RATTCCVMLI LAAPMMFLYN YIGQDGIASS IVMLIICGGL VNGPYALITT AVSADLGTHK
   421  SLKGNAKALS TVTAIIDGTG SIGAALGPLL AGLISPTGWN NVFYMLISAD VLACLLLCRL
   481  VYKEILAWKV SLSRGSGYKE I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC37A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 11
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 74 nTPM
adrenal gland: 49 nTPM
skin: 37 nTPM
appendix: 16 nTPM
spleen: 15 nTPM
vagina: 15 nTPM

Single-cell type

adrenal cortex cells: 95 nCPM
hofbauer cells: 92 nCPM
esophageal apical cells: 71 nCPM
kupffer cells: 71 nCPM
macrophages: 61 nCPM
salivary acinar cells: 48 nCPM

Immune cell

non-classical monocyte: 19 nTPM
intermediate monocyte: 14 nTPM
classical monocyte: 12 nTPM
myeloid DC: 5.5 nTPM
total PBMC: 5.4 nTPM
neutrophil: 1.3 nTPM

Brain region

white matter: 18 nTPM
thalamus: 14 nTPM
medulla oblongata: 11 nTPM
spinal cord: 9.3 nTPM
pons: 9.2 nTPM
cerebral cortex: 8.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: 0.67
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

glucose 6-phosphate:phosphate antiporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC37A2 as an antibody target. Whether an autoantibody or antibody against SLC37A2 could matter depends on whether native SLC37A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC37A2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC37A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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