Seroatlas · Human Serome Atlas

SLC37A1

Glucose-6-phosphate exchanger SLC37A1

Also known as: G6PT2_HUMAN, SPX1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P57057
Gene: SLC37A1
Ensembl: ENSG00000160190
Chromosome: 21
Canonical length: 533 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene localizes to the endoplasmic reticulum (ER) membrane. This protein translocates glucose-6-phosphate from the cytoplasm into the lumen of the ER for hydrolysis into glucose by another ER membrane protein. This gene is a member of the solute carrier 37 gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

533 residues, UniProt reviewed canonical sequence.

>P57057|SLC37A1
     1  MARLPAGIRF IISFSRDQWY RAFIFILTFL LYASFHLSRK PISIVKGELH KYCTAWDEAD
    61  VRFSSQNRKS GSAAPHQLPD NETDCGWAPF DKNNYQQLLG ALDYSFLCAY AVGMYLSGII
   121  GERLPIRYYL TFGMLASGAF TALFGLGYFY NIHSFGFYVV TQVINGLVQT TGWPSVVTCL
   181  GNWFGKGRRG LIMGVWNSHT SVGNILGSLI AGYWVSTCWG LSFVVPGAIV AAMGIVCFLF
   241  LIEHPNDVRC SSTLVTHSKG YENGTNRLRL QKQILKSEKN KPLDPEMQCL LLSDGKGSIH
   301  PNHVVILPGD GGSGTAAISF TGALKIPGVI EFSLCLLFAK LVSYTFLFWL PLYITNVDHL
   361  DAKKAGELST LFDVGGIFGG ILAGVISDRL EKRASTCGLM LLLAAPTLYI FSTVSKMGLE
   421  ATIAMLLLSG ALVSGPYTLI TTAVSADLGT HKSLKGNAHA LSTVTAIIDG TGSVGAALGP
   481  LLAGLLSPSG WSNVFYMLMF ADACALLFLI RLIHKELSCP GSATGDQVPF KEQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC37A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

duodenum: 43 nTPM
small intestine: 37 nTPM
stomach: 23 nTPM
colon: 22 nTPM
salivary gland: 19 nTPM
rectum: 18 nTPM

Single-cell type

breast lactating cells: 682 nCPM
somatotrophs: 246 nCPM
megakaryocyte progenitors: 222 nCPM
early spermatids: 211 nCPM
megakaryocytes: 210 nCPM
müller glia: 208 nCPM

Immune cell

eosinophil: 37 nTPM
plasmacytoid DC: 20 nTPM
non-classical monocyte: 17 nTPM
intermediate monocyte: 13 nTPM
memory B-cell: 11 nTPM
MAIT T-cell: 9.6 nTPM

Brain region

amygdala: 18 nTPM
hypothalamus: 17 nTPM
cerebral cortex: 15 nTPM
medulla oblongata: 15 nTPM
basal ganglia: 15 nTPM
thalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0
gnomAD missense Z: 1.3
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

glucose 6-phosphate:phosphate antiporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC37A1 as an antibody target. Whether an autoantibody or antibody against SLC37A1 could matter depends on whether native SLC37A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC37A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC37A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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