SLC35F1
Solute carrier family 35 member F1
Also known as: C6orf169, dJ230I3.1, S35F1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5T1Q4
- Gene
- SLC35F1
- Ensembl
- ENSG00000196376
- Chromosome
- 6
- Canonical length
- 408 aa
- Protein class
- Predicted membrane proteins, Transporters
- Subcellular location
- Nucleoplasm,Centriolar satellite,Cytosol
OverviewNCBI Gene
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Located in synaptic vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
408 residues, UniProt reviewed canonical sequence.
>Q5T1Q4|SLC35F1
1 MIPPEQPQQQ LQPPSPAPPN HVVTTIENLP AEGSGGGGSL SASSRAGVRQ RIRKVLNREM
61 LISVALGQVL SLLICGIGLT SKYLSEDFHA NTPVFQSFLN YILLFLVYTT TLAVRQGEEN
121 LLAILRRRWW KYMILGLIDL EANYLVVKAY QYTTLTSIQL LDCFVIPVVI LLSWFFLLIR
181 YKAVHFIGIV VCILGMGCMV GADVLVGRHQ GAGENKLVGD LLVLGGATLY GISNVWEEYI
241 IRTLSRVEFL GMIGLFGAFF SGIQLAIMEH KELLKVPWDW QIGLLYVGFS ACMFGLYSFM
301 PVVIKKTSAT SVNLSLLTAD LYSLFCGLFL FHYKFSGLYL LSFFTILIGL VLYSSTSTYI
361 AQDPRVYKQF RNPSGPVVDL PTTAQVEPSV TYTSLGQETE EEPHVRVALocalizationUniProt · AlphaFold · HPA
Whether an antibody against SLC35F1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 10
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 25 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 25 nTPM
- basal ganglia: 15 nTPM
- amygdala: 15 nTPM
- hippocampal formation: 12 nTPM
- retina: 12 nTPM
- hypothalamus: 12 nTPM
Single-cell type
- oligodendrocyte progenitor cells: 2,099 nCPM
- schwann cells: 939 nCPM
- bergmann glia: 760 nCPM
- brain inhibitory neurons: 463 nCPM
- astrocytes: 446 nCPM
- retinal bipolar cells: 347 nCPM
Immune cell
- neutrophil: 0.3 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebral cortex: 42 nTPM
- basal ganglia: 41 nTPM
- white matter: 35 nTPM
- midbrain: 28 nTPM
- hypothalamus: 27 nTPM
- hippocampal formation: 25 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.34
- gnomAD pLI
- 0.95
- gnomAD missense Z
- 1.78
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SLC35F1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SLC35F1 as an antibody target. Whether an autoantibody or antibody against SLC35F1 could matter depends on whether native SLC35F1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SLC35F1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SLC35F1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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