Seroatlas · Human Serome Atlas

SLC35B2

Adenosine 3'-phospho 5'-phosphosulfate transporter 1

Also known as: S35B2_HUMAN, UGTrel4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TB61
Gene: SLC35B2
Ensembl: ENSG00000157593
Chromosome: 6
Canonical length: 432 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location: Vesicles

OverviewNCBI Gene

Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

432 residues, UniProt reviewed canonical sequence.

>Q8TB61|SLC35B2
     1  MDARWWAVVV LAAFPSLGAG GETPEAPPES WTQLWFFRFV VNAAGYASFM VPGYLLVQYF
    61  RRKNYLETGR GLCFPLVKAC VFGNEPKASD EVPLAPRTEA AETTPMWQAL KLLFCATGLQ
   121  VSYLTWGVLQ ERVMTRSYGA TATSPGERFT DSQFLVLMNR VLALIVAGLS CVLCKQPRHG
   181  APMYRYSFAS LSNVLSSWCQ YEALKFVSFP TQVLAKASKV IPVMLMGKLV SRRSYEHWEY
   241  LTATLISIGV SMFLLSSGPE PRSSPATTLS GLILLAGYIA FDSFTSNWQD ALFAYKMSSV
   301  QMMFGVNFFS CLFTVGSLLE QGALLEGTRF MGRHSEFAAH ALLLSICSAC GQLFIFYTIG
   361  QFGAAVFTII MTLRQAFAIL LSCLLYGHTV TVVGGLGVAV VFAALLLRVY ARGRLKQRGK
   421  KAVPVESPVQ KV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC35B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 46 nTPM
salivary gland: 44 nTPM
parathyroid gland: 40 nTPM
pancreas: 39 nTPM
adrenal gland: 36 nTPM
spinal cord: 34 nTPM

Single-cell type

melanocytes: 84 nCPM
differentiating spermatogonia: 70 nCPM
cytotrophoblasts: 69 nCPM
extravillous trophoblasts: 66 nCPM
migrating cytotrophoblasts: 57 nCPM
decidual stromal cells: 53 nCPM

Immune cell

basophil: 52 nTPM
gdT-cell: 33 nTPM
MAIT T-cell: 28 nTPM
memory CD8 T-cell: 25 nTPM
eosinophil: 24 nTPM
plasmacytoid DC: 24 nTPM

Brain region

cerebral cortex: 45 nTPM
white matter: 43 nTPM
thalamus: 36 nTPM
cerebellum: 36 nTPM
spinal cord: 35 nTPM
medulla oblongata: 34 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC35B2.

Disease | AllUniProt

Conditions SLC35B2 is implicated in, by any mechanism.

Leukodystrophy, hypomyelinating, 26, with chondrodysplasia (HLD26) MIM:620269

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 102 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Leukodystrophy, hypomyelinating, 26, with chondrodysplasia
Primary bone dysplasia with multiple joint dislocations

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0.07
gnomAD missense Z: -0.26
DepMap mean gene effect: -0.34
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC35B2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GOLM1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC35B2 as an antibody target. Whether an autoantibody or antibody against SLC35B2 could matter depends on whether native SLC35B2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC35B2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC35B2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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