Seroatlas · Human Serome Atlas

GOLM1

Golgi membrane protein 1

Also known as: bA379P1.3, C9orf155, FLJ23608, GOLM1_HUMAN, GOLPH2, GP73

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NBJ4
Gene
GOLM1
Ensembl
ENSG00000135052
Chromosome
9
Canonical length
401 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

401 residues, UniProt reviewed canonical sequence.

>Q8NBJ4|GOLM1
     1  MMGLGNGRRS MKSPPLVLAA LVACIIVLGF NYWIASSRSV DLQTRIMELE GRVRRAAAER
    61  GAVELKKNEF QGELEKQREQ LDKIQSSHNF QLESVNKLYQ DEKAVLVNNI TTGERLIRVL
   121  QDQLKTLQRN YGRLQQDVLQ FQKNQTNLER KFSYDLSQCI NQMKEVKEQC EERIEEVTKK
   181  GNEAVASRDL SENNDQRQQL QALSEPQPRL QAAGLPHTEV PQGKGNVLGN SKSQTPAPSS
   241  EVVLDSKRQV EKEETNEIQV VNEEPQRDRL PQEPGREQVV EDRPVGGRGF GGAGELGQTP
   301  QVQAALSVSQ ENPEMEGPER DQLVIPDGQE EEQEAAGEGR NQQKLRGEDD YNMDENEAES
   361  ETDKQAALAG NDRNIDVFNV EDQKRDTINL LDQREKRNHT L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
375 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 375 nTPM
  • duodenum: 222 nTPM
  • colon: 184 nTPM
  • salivary gland: 169 nTPM
  • choroid plexus: 155 nTPM
  • rectum: 154 nTPM

Single-cell type

  • foveolar cells: 750 nCPM
  • respiratory ionocytes: 607 nCPM
  • late spermatids: 513 nCPM
  • early spermatids: 437 nCPM
  • colonocytes: 397 nCPM
  • respiratory deuterosomal cells: 343 nCPM

Immune cell

  • neutrophil: 4.3 nTPM
  • non-classical monocyte: 4.2 nTPM
  • classical monocyte: 3.5 nTPM
  • gdT-cell: 3.5 nTPM
  • intermediate monocyte: 2.6 nTPM
  • basophil: 2.2 nTPM

Brain region

  • hypothalamus: 146 nTPM
  • choroid plexus: 129 nTPM
  • spinal cord: 90 nTPM
  • white matter: 85 nTPM
  • basal ganglia: 84 nTPM
  • midbrain: 81 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0
gnomAD missense Z
0.76
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GOLM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLM1 as an antibody target. Whether an autoantibody or antibody against GOLM1 could matter depends on whether native GOLM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLM1 is annotated at the cell surface, where native GOLM1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GOLM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GOLM1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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