Seroatlas · Human Serome Atlas

SLC2A6

Solute carrier family 2, facilitated glucose transporter member 6

Also known as: GLUT6, GLUT9, GTR6_HUMAN, HSA011372

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UGQ3
Gene: SLC2A6
Ensembl: ENSG00000160326
Chromosome: 9
Canonical length: 507 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Hexose transport into mammalian cells is catalyzed by a family of membrane proteins, including SLC2A6, that contain 12 transmembrane domains and a number of critical conserved residues.[supplied by OMIM, Jul 2002]

Canonical amino-acid sequenceUniProt

507 residues, UniProt reviewed canonical sequence.

>Q9UGQ3|SLC2A6
     1  MQEPLLGAEG PDYDTFPEKP PPSPGDRARV GTLQNKRVFL ATFAAVLGNF SFGYALVYTS
    61  PVIPALERSL DPDLHLTKSQ ASWFGSVFTL GAAAGGLSAM ILNDLLGRKL SIMFSAVPSA
   121  AGYALMAGAH GLWMLLLGRT LTGFAGGLTA ACIPVYVSEI APPGVRGALG ATPQLMAVFG
   181  SLSLYALGLL LPWRWLAVAG EAPVLIMILL LSFMPNSPRF LLSRGRDEEA LRALAWLRGT
   241  DVDVHWEFEQ IQDNVRRQSS RVSWAEARAP HVCRPITVAL LMRLLQQLTG ITPILVYLQS
   301  IFDSTAVLLP PKDDAAIVGA VRLLSVLIAA LTMDLAGRKV LLFVSAAIMF AANLTLGLYI
   361  HFGPRPLSPN STAGLESESW GDLAQPLAAP AGYLTLVPLL ATMLFIMGYA VGWGPITWLL
   421  MSEVLPLRAR GVASGLCVLA SWLTAFVLTK SFLPVVSTFG LQVPFFFFAA ICLVSLVFTG
   481  CCVPETKGRS LEQIESFFRT GRRSFLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC2A6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 18 nTPM
hypothalamus: 14 nTPM
spleen: 14 nTPM
midbrain: 13 nTPM
hippocampal formation: 11 nTPM
cerebellum: 10 nTPM

Single-cell type

other brain neurons: 25 nCPM
brain excitatory neurons: 19 nCPM
brain inhibitory neurons: 16 nCPM
astrocytes: 9.7 nCPM
oligodendrocyte progenitor cells: 7.2 nCPM
oligodendrocytes: 6.8 nCPM

Immune cell

non-classical monocyte: 74 nTPM
basophil: 46 nTPM
intermediate monocyte: 37 nTPM
classical monocyte: 18 nTPM
plasmacytoid DC: 17 nTPM
myeloid DC: 16 nTPM

Brain region

pons: 26 nTPM
cerebral cortex: 20 nTPM
medulla oblongata: 19 nTPM
thalamus: 18 nTPM
hypothalamus: 17 nTPM
midbrain: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0
gnomAD missense Z: 0.81
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC2A6 as an antibody target. Whether an autoantibody or antibody against SLC2A6 could matter depends on whether native SLC2A6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC2A6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC2A6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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