Seroatlas · Human Serome Atlas

SLC2A12

Solute carrier family 2, facilitated glucose transporter member 12

Also known as: GLUT12, GLUT8, GTR12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TD20
Gene
SLC2A12
Ensembl
ENSG00000146411
Chromosome
6
Canonical length
617 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Cell Junctions

OverviewNCBI Gene

SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

617 residues, UniProt reviewed canonical sequence.

>Q8TD20|SLC2A12
     1  MVPVENTEGP SLLNQKGTAV ETEGSGSRHP PWARGCGMFT FLSSVTAAVS GLLVGYELGI
    61  ISGALLQIKT LLALSCHEQE MVVSSLVIGA LLASLTGGVL IDRYGRRTAI ILSSCLLGLG
   121  SLVLILSLSY TVLIVGRIAI GVSISLSSIA TCVYIAEIAP QHRRGLLVSL NELMIVIGIL
   181  SAYISNYAFA NVFHGWKYMF GLVIPLGVLQ AIAMYFLPPS PRFLVMKGQE GAASKVLGRL
   241  RALSDTTEEL TVIKSSLKDE YQYSFWDLFR SKDNMRTRIM IGLTLVFFVQ ITGQPNILFY
   301  ASTVLKSVGF QSNEAASLAS TGVGVVKVIS TIPATLLVDH VGSKTFLCIG SSVMAASLVT
   361  MGIVNLNIHM NFTHICRSHN SINQSLDESV IYGPGNLSTN NNTLRDHFKG ISSHSRSSLM
   421  PLRNDVDKRG ETTSASLLNA GLSHTEYQIV TDPGDVPAFL KWLSLASLLV YVAAFSIGLG
   481  PMPWLVLSEI FPGGIRGRAM ALTSSMNWGI NLLISLTFLT VTDLIGLPWV CFIYTIMSLA
   541  SLLFVVMFIP ETKGCSLEQI SMELAKVNYV KNNICFMSHH QEELVPKQPQ KRKPQEQLLE
   601  CNKLCGRGQS RQLSPET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC2A12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
102 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 102 nTPM
  • prostate: 21 nTPM
  • stomach: 14 nTPM
  • heart muscle: 10 nTPM
  • small intestine: 9.2 nTPM
  • seminal vesicle: 8.7 nTPM

Single-cell type

  • choroid plexus epithelial cells: 993 nCPM
  • retinal pigment epithelial cells: 601 nCPM
  • prostatic glandular cells: 132 nCPM
  • cardiomyocytes: 128 nCPM
  • parietal cells: 106 nCPM
  • respiratory ionocytes: 89 nCPM

Immune cell

  • intermediate monocyte: 0.1 nTPM
  • myeloid DC: 0.1 nTPM
  • non-classical monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • choroid plexus: 185 nTPM
  • cerebellum: 16 nTPM
  • hippocampal formation: 12 nTPM
  • basal ganglia: 9.8 nTPM
  • cerebral cortex: 8.9 nTPM
  • thalamus: 7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0
gnomAD missense Z
1.31
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC2A12 as an antibody target. Whether an autoantibody or antibody against SLC2A12 could matter depends on whether native SLC2A12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC2A12 is annotated at the cell surface, where native SLC2A12 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC2A12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC2A12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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