Seroatlas · Human Serome Atlas

SLC2A10

Solute carrier family 2, facilitated glucose transporter member 10

Also known as: GLUT-10, GLUT10, GTR10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95528
Gene
SLC2A10
Ensembl
ENSG00000197496
Chromosome
20
Canonical length
541 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.[provided by RefSeq, Dec 2009]

Canonical amino-acid sequenceUniProt

541 residues, UniProt reviewed canonical sequence.

>O95528|SLC2A10
     1  MGHSPPVLPL CASVSLLGGL TFGYELAVIS GALLPLQLDF GLSCLEQEFL VGSLLLGALL
    61  ASLVGGFLID CYGRKQAILG SNLVLLAGSL TLGLAGSLAW LVLGRAVVGF AISLSSMACC
   121  IYVSELVGPR QRGVLVSLYE AGITVGILLS YALNYALAGT PWGWRHMFGW ATAPAVLQSL
   181  SLLFLPAGTD ETATHKDLIP LQGGEAPKLG PGRPRYSFLD LFRARDNMRG RTTVGLGLVL
   241  FQQLTGQPNV LCYASTIFSS VGFHGGSSAV LASVGLGAVK VAATLTAMGL VDRAGRRALL
   301  LAGCALMALS VSGIGLVSFA VPMDSGPSCL AVPNATGQTG LPGDSGLLQD SSLPPIPRTN
   361  EDQREPILST AKKTKPHPRS GDPSAPPRLA LSSALPGPPL PARGHALLRW TALLCLMVFV
   421  SAFSFGFGPV TWLVLSEIYP VEIRGRAFAF CNSFNWAANL FISLSFLDLI GTIGLSWTFL
   481  LYGLTAVLGL GFIYLFVPET KGQSLAEIDQ QFQKRRFTLS FGHRQNSTGI PYSRIEISAA
   541  S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC2A10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • liver: 40 nTPM
  • prostate: 29 nTPM
  • salivary gland: 24 nTPM
  • stomach: 22 nTPM
  • choroid plexus: 19 nTPM
  • parathyroid gland: 18 nTPM

Single-cell type

  • prostatic glandular cells: 102 nCPM
  • goblet cells: 84 nCPM
  • hepatocytes: 60 nCPM
  • foveolar cells: 58 nCPM
  • breast hormone-responsive cells: 53 nCPM
  • respiratory secretory cells: 51 nCPM

Immune cell

  • basophil: 21 nTPM
  • NK-cell: 0.2 nTPM
  • neutrophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • choroid plexus: 39 nTPM
  • medulla oblongata: 9.8 nTPM
  • midbrain: 8.9 nTPM
  • thalamus: 7.4 nTPM
  • basal ganglia: 7.2 nTPM
  • amygdala: 7.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC2A10.

Disease | AllUniProt

Conditions SLC2A10 is implicated in, by any mechanism.

Disease | GeneticClinVar

55 pathogenic / likely-pathogenic of 747 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.39
gnomAD pLI
0
gnomAD missense Z
-0.75
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC2A10 as an antibody target. Whether an autoantibody or antibody against SLC2A10 could matter depends on whether native SLC2A10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC2A10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC2A10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC2A10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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