Seroatlas · Human Serome Atlas

SLC29A4

Equilibrative nucleoside transporter 4

Also known as: ENT4, FLJ34923, S29A4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7RTT9
Gene
SLC29A4
Ensembl
ENSG00000164638
Chromosome
7
Canonical length
530 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Microtubules,Cytokinetic bridge

OverviewNCBI Gene

This gene encodes a member of the SLC29A/ENT transporter protein family. The encoded membrane protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

530 residues, UniProt reviewed canonical sequence.

>Q7RTT9|SLC29A4
     1  MGSVGSQRLE EPSVAGTPDP GVVMSFTFDS HQLEEAAEAA QGQGLRARGV PAFTDTTLDE
    61  PVPDDRYHAI YFAMLLAGVG FLLPYNSFIT DVDYLHHKYP GTSIVFDMSL TYILVALAAV
   121  LLNNVLVERL TLHTRITAGY LLALGPLLFI SICDVWLQLF SRDQAYAINL AAVGTVAFGC
   181  TVQQSSFYGY TGMLPKRYTQ GVMTGESTAG VMISLSRILT KLLLPDERAS TLIFFLVSVA
   241  LELLCFLLHL LVRRSRFVLF YTTRPRDSHR GRPGLGRGYG YRVHHDVVAG DVHFEHPAPA
   301  LAPNESPKDS PAHEVTGSGG AYMRFDVPRP RVQRSWPTFR ALLLHRYVVA RVIWADMLSI
   361  AVTYFITLCL FPGLESEIRH CILGEWLPIL IMAVFNLSDF VGKILAALPV DWRGTHLLAC
   421  SCLRVVFIPL FILCVYPSGM PALRHPAWPC IFSLLMGISN GYFGSVPMIL AAGKVSPKQR
   481  ELAGNTMTVS YMSGLTLGSA VAYCTYSLTR DAHGSCLHAS TANGSILAGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC29A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
10
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 41 nTPM
  • choroid plexus: 35 nTPM
  • hypothalamus: 32 nTPM
  • cerebral cortex: 26 nTPM
  • midbrain: 25 nTPM
  • hippocampal formation: 21 nTPM

Single-cell type

  • retinal horizontal cells: 210 nCPM
  • neuroendocrine cells: 112 nCPM
  • retinal pigment epithelial cells: 90 nCPM
  • choroid plexus epithelial cells: 76 nCPM
  • adrenal medulla cells: 75 nCPM
  • pancreatic islet cells: 66 nCPM

Immune cell

  • NK-cell: 1.6 nTPM
  • neutrophil: 1.3 nTPM
  • basophil: 0.7 nTPM
  • MAIT T-cell: 0.4 nTPM
  • naive B-cell: 0.4 nTPM
  • classical monocyte: 0.3 nTPM

Brain region

  • choroid plexus: 126 nTPM
  • thalamus: 69 nTPM
  • hypothalamus: 66 nTPM
  • midbrain: 65 nTPM
  • hippocampal formation: 61 nTPM
  • pons: 58 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0
gnomAD missense Z
-1
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC29A4 as an antibody target. Whether an autoantibody or antibody against SLC29A4 could matter depends on whether native SLC29A4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC29A4 is annotated at the cell surface, where native SLC29A4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC29A4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC29A4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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