Seroatlas · Human Serome Atlas

SLC22A9

Organic anion transporter 7

Also known as: FLJ23666, OAT4, OAT7, S22A9_HUMAN, UST3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IVM8
Gene
SLC22A9
Ensembl
ENSG00000149742
Chromosome
11
Canonical length
553 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables short-chain fatty acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Involved in hormone transport; short-chain fatty acid transmembrane transport; and sodium-independent organic anion transport. Located in basolateral plasma membrane. Implicated in Lynch syndrome and mismatch repair cancer syndrome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

553 residues, UniProt reviewed canonical sequence.

>Q8IVM8|SLC22A9
     1  MAFQDLLGHA GDLWRFQILQ TVFLSIFAVA TYLHFMLENF TAFIPGHRCW VHILDNDTVS
    61  DNDTGALSQD ALLRISIPLD SNMRPEKCRR FVHPQWQLLH LNGTFPNTSD ADMEPCVDGW
   121  VYDRISFSST IVTEWDLVCD SQSLTSVAKF VFMAGMMVGG ILGGHLSDRF GRRFVLRWCY
   181  LQVAIVGTCA ALAPTFLIYC SLRFLSGIAA MSLITNTIML IAEWATHRFQ AMGITLGMCP
   241  SGIAFMTLAG LAFAIRDWHI LQLVVSVPYF VIFLTSSWLL ESARWLIINN KPEEGLKELR
   301  KAAHRSGMKN ARDTLTLEIL KSTMKKELEA AQKKKPSLCE MLHMPNICKR ISLLSFTRFA
   361  NFMAYFGLNL HVQHLGNNVF LLQTLFGAVI LLANCVAPWA LKYMNRRASQ MLLMFLLAIC
   421  LLAIIFVPQE MQTLREVLAT LGLGASALAN TLAFAHGNEV IPTIIRARAM GINATFANIA
   481  GALAPLMMIL SVYSPPLPWI IYGVFPFISG FAFLLLPETR NKPLFDTIQD EKNERKDPRE
   541  PKQEDPRVEV TQF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC22A9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
43 nTPM

Expression across tissuesHPA

Tissue

  • liver: 43 nTPM
  • skeletal muscle: 1.4 nTPM
  • cerebral cortex: 0.9 nTPM
  • amygdala: 0.4 nTPM
  • gallbladder: 0.3 nTPM
  • bone marrow: 0.2 nTPM

Single-cell type

  • hepatocytes: 33 nCPM
  • adipocytes: 6.6 nCPM
  • brain excitatory neurons: 6.5 nCPM
  • epididymal efferent duct absorptive cells: 2.8 nCPM
  • epicardial cells: 2.3 nCPM
  • brain inhibitory neurons: 2.1 nCPM

Immune cell

  • basophil: 0.8 nTPM
  • neutrophil: 0.3 nTPM
  • eosinophil: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • memory B-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM

Brain region

  • cerebral cortex: 6.3 nTPM
  • white matter: 3.5 nTPM
  • amygdala: 3.4 nTPM
  • basal ganglia: 3.4 nTPM
  • hypothalamus: 2.3 nTPM
  • hippocampal formation: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.61
gnomAD pLI
0
gnomAD missense Z
-1.24
DepMap mean gene effect
-0.21
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC22A9 as an antibody target. Whether an autoantibody or antibody against SLC22A9 could matter depends on whether native SLC22A9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC22A9 is annotated at the cell surface, where native SLC22A9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC22A9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC22A9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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