Seroatlas · Human Serome Atlas

SLC22A31

Putative solute carrier family 22 member 31

Also known as: S22AV_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NKX4
Gene: SLC22A31
Ensembl: ENSG00000259803
Chromosome: 16
Canonical length: 556 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic ion transport and transmembrane transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

556 residues, UniProt reviewed canonical sequence.

>A6NKX4|SLC22A31
     1  MEQEARVLRA AGGFGRARRL LASASWVPCI VLGLVLSSEE LLTAQPAPHC RPDPTLLPPA
    61  LRALRGPALL DAAIPRLGPT RAPAEALGVL SPSYLAPLTR APRPSSWASC SGAAAGPTWN
   121  LVCGDGWKVP LEQVSHLLGW LLGCVILGAG CDRFGRRAVF VASLVLTTGL GASEALAASF
   181  PTLLVLRLLH GGTLAGALLA LYLARLELCD PPHRLAFSMG AGLFSVVGTL LLPGLAALVQ
   241  DWRLLQGLGA LMSGLLLLFW GFPALFPESP CWLLATGQVA RARKILWRFA EASGVGPGDS
   301  SLEENSLATE LTMLSARSPQ PRYHSPLGLL RTRVTWRNGL ILGFSSLVGG GIRASFRRSL
   361  APQVPTFYLP YFLEAGLEAA ALVFLLLTAD CCGRRPVLLL GTMVTGLASL LLLAGAQYLP
   421  GWTVLFLSVL GLLASRAVSA LSSLFAAEVF PTVIRGAGLG LVLGAGFLGQ AAGPLDTLHG
   481  RQGFFLQQVV FASLAVLALL CVLLLPESRS RGLPQSLQDA DRLRRSPLLR GRPRQDHLPL
   541  LPPSNSYWAG HTPEQH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC22A31 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 133 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 133 nTPM
lung: 26 nTPM
pancreas: 19 nTPM
testis: 4.2 nTPM
spleen: 2.3 nTPM
ovary: 2 nTPM

Single-cell type

alveolar cells type 2: 262 nCPM
transitional alveolar cells: 144 nCPM
late spermatids: 63 nCPM
alveolar cells type 1: 61 nCPM
brain excitatory neurons: 30 nCPM
early spermatids: 26 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 63 nTPM
pons: 6.6 nTPM
midbrain: 3 nTPM
cerebral cortex: 2.7 nTPM
medulla oblongata: 1.5 nTPM
white matter: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.81
gnomAD pLI: 0
gnomAD missense Z: -0.19

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC22A31 as an antibody target. Whether an autoantibody or antibody against SLC22A31 could matter depends on whether native SLC22A31 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC22A31 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC22A31 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...