Seroatlas · Human Serome Atlas

SLC22A25

Solute carrier family 22 member 25

Also known as: HIMTP, MGC120420, S22AP_HUMAN, UST6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6T423
Gene: SLC22A25
Ensembl: ENSG00000196600
Chromosome: 11
Canonical length: 547 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

547 residues, UniProt reviewed canonical sequence.

>Q6T423|SLC22A25
     1  MAFQDLLDQV GGLGRFQILQ MVFLIMFNVI VYHQTQLENF AAFILDHRCW VHILDNDTIP
    61  DNDPGTLSQD ALLRISIPFD SNLRPEKCRR FVHPQWKLIH LNGTFPNTSE PDTEPCVDGW
   121  VYDQSSFPST IVTKWDLVCE SQPLNSVAKF LFMAGMMVGG NLYGHLSDRF GRKFVLRWSY
   181  LQLAIVGTCA AFAPTILVYC SLRFLAGAAT FSIIVNTVLL IVEWITHQFC AMALTLTLCA
   241  ASIGHITLGS LAFVIRDQCI LQLVMSAPCF VFFLFSRWLA ESARWLIINN KPEEGLKELR
   301  KAAHRNGMKN AEDILTMEVL KSTMKQELEA AQKKHSLCEL LRIPNICKRI CFLSFVRFAS
   361  TIPFWGLTLH LQHLGNNVFL LQTLFGAVTL LANCVAPWAL NHMSRRLSQM LLMFLLATCL
   421  LAIIFVPQEM QTLRVVLATL GVGAASLGIT CSTAQENELI PSIIRGRATG ITGNFANIGG
   481  ALASLMMILS IYSRPLPWII YGVFAILSGL VVLLLPETRN QPLLDSIQDV ENEGVNSLAA
   541  PQRSSVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC22A25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

liver: 30 nTPM
retina: 2.3 nTPM
bone marrow: 1.6 nTPM
epididymis: 1 nTPM
skeletal muscle: 1 nTPM
skin: 1 nTPM

Single-cell type

hepatocytes: 120 nCPM
adipocytes: 25 nCPM
epididymal clear cells: 18 nCPM
brain excitatory neurons: 3.9 nCPM
mast cells: 3.8 nCPM
salivary acinar cells: 3 nCPM

Immune cell

basophil: 0.4 nTPM
neutrophil: 0.2 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM

Brain region

cerebral cortex: 26 nTPM
basal ganglia: 23 nTPM
amygdala: 23 nTPM
cerebellum: 23 nTPM
white matter: 23 nTPM
hypothalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: -1.44
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC22A25 as an antibody target. Whether an autoantibody or antibody against SLC22A25 could matter depends on whether native SLC22A25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC22A25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC22A25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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