Seroatlas · Human Serome Atlas

SLC22A24

Steroid transmembrane transporter SLC22A24

Also known as: MGC34821, NET46, S22AO_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N4F4
Gene: SLC22A24
Ensembl: ENSG00000197658
Chromosome: 11
Canonical length: 552 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

SLC22A24 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

552 residues, UniProt reviewed canonical sequence.

>Q8N4F4|SLC22A24
     1  MGFDVLLDQV GGMGRFQICL IAFFCITNIL LFPNIVLENF TAFTPSHRCW VPLLDNDTVS
    61  DNDTGTLSKD DLLRISIPLD SNLRPQKCQR FIHPQWQLLH LNGTFPNTNE PDTEPCVDGW
   121  VYDRSSFLST IVTEWDLVCE SQSLKSMVQS LFMAGSLLGG LIYGHLSDRV GRKIICKLCF
   181  LQLAISNTCA AFAPTFLVYC ILRFLAGFST MTILGNTFIL SLEWTLPRSR SMTIMVLLCS
   241  YSVGQMLLGG LAFAIQDWHI LQLTVSTPII VLFLSSWKMV ESARWLIINN QLDEGLKELR
   301  RVAHINGKKN TEETLTTELV RSTMKKELDA VRIKTSIFSL FRAPKLRMRV FGLCFVRFAI
   361  TVPFYGLILN LQHLGSNVSL FQILCGAVTF TARCVSLLTL NHMGRRISQI LFTFPVGLFI
   421  LVNTFLPQEM QILRVVLATL GIGSVSAASN SASVHHNELV PTILRSTVAG INAVSGRTGA
   481  ALAPLLMTLM AYSPHLPWIS YGVFPILAVP VILLLPETRD LPLPNTIQDV ENDRKDSRNI
   541  KQEDTCMKVT QF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC22A24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 4.1 nTPM

Expression across tissuesHPA

Tissue

kidney: 4.1 nTPM
liver: 0.4 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

proximal tubule cells: 76 nCPM
brain excitatory neurons: 8.9 nCPM
mast cells: 6.2 nCPM
epididymal clear cells: 6.1 nCPM
epididymal efferent duct absorptive cells: 3.9 nCPM
renal connecting tubule cells: 2.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 6.4 nTPM
amygdala: 2.9 nTPM
white matter: 2.8 nTPM
basal ganglia: 2.7 nTPM
hypothalamus: 1.4 nTPM
hippocampal formation: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.46
gnomAD pLI: 0
gnomAD missense Z: 0.1

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transmembrane transporter activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC22A24 as an antibody target. Whether an autoantibody or antibody against SLC22A24 could matter depends on whether native SLC22A24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC22A24 is annotated at the cell surface, where native SLC22A24 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC22A24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...