Seroatlas · Human Serome Atlas

SLC22A23

Solute carrier family 22 member 23

Also known as: C6orf85, FLJ22174, S22AN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A1A5C7
Gene
SLC22A23
Ensembl
ENSG00000137266
Chromosome
6
Canonical length
686 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

SLC22A23 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

686 residues, UniProt reviewed canonical sequence.

>A1A5C7|SLC22A23
     1  MAIDRRREAA GGGPGRQPAP AEENGSLPPG DAAASAPLGG RAGPGGGAEI QPLPPLHPGG
    61  GPHPSCCSAA AAPSLLLLDY DGSVLPFLGG LGGGYQKTLV LLTWIPALFI GFSQFSDSFL
   121  LDQPNFWCRG AGKGTELAGV TTTGRGGDMG NWTSLPTTPF ATAPWEAAGN RSNSSGADGG
   181  DTPPLPSPPD KGDNASNCDC RAWDYGIRAG LVQNVVSKWD LVCDNAWKVH IAKFSLLVGL
   241  IFGYLITGCI ADWVGRRPVL LFSIIFILIF GLTVALSVNV TMFSTLRFFE GFCLAGIILT
   301  LYALRIELCP PGKRFMITMV ASFVAMAGQF LMPGLAALCR DWQVLQALII CPFLLMLLYW
   361  SIFPESLRWL MATQQFESAK RLILHFTQKN RMNPEGDIKG VIPELEKELS RRPKKVCIVK
   421  VVGTRNLWKN IVVLCVNSLT GYGIHHCFAR SMMGHEVKVP LLENFYADYY TTASIALVSC
   481  LAMCVVVRFL GRRGGLLLFM ILTALASLLQ LGLLNLIGKY SQHPDSGMSD SVKDKFSIAF
   541  SIVGMFASHA VGSLSVFFCA EITPTVIRCG GLGLVLASAG FGMLTAPIIE LHNQKGYFLH
   601  HIIFACCTLI CIICILLLPE SRDQNLPENI SNGEHYTRQP LLPHKKGEQP LLLTNAELKD
   661  YSGLHDAAAA GDTLPEGATA NGMKAM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC22A23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
10
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 26 nTPM
  • stomach: 25 nTPM
  • esophagus: 22 nTPM
  • small intestine: 21 nTPM
  • spinal cord: 21 nTPM
  • duodenum: 20 nTPM

Single-cell type

  • prostatic glandular cells: 845 nCPM
  • foveolar cells: 612 nCPM
  • renal collecting duct intercalated cells: 500 nCPM
  • late spermatids: 429 nCPM
  • goblet cells: 381 nCPM
  • oligodendrocytes: 360 nCPM

Immune cell

  • naive CD4 T-cell: 0.2 nTPM
  • total PBMC: 0.2 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM

Brain region

  • white matter: 120 nTPM
  • pons: 82 nTPM
  • medulla oblongata: 81 nTPM
  • thalamus: 81 nTPM
  • midbrain: 81 nTPM
  • basal ganglia: 78 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.83
gnomAD missense Z
1.87
DepMap mean gene effect
-0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC22A23 as an antibody target. Whether an autoantibody or antibody against SLC22A23 could matter depends on whether native SLC22A23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC22A23 is annotated at the cell surface, where native SLC22A23 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC22A23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC22A23. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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