Seroatlas · Human Serome Atlas

SLC22A16

Solute carrier family 22 member 16

Also known as: CT2, FLIPT2, OAT6, OKB1, S22AG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86VW1
Gene
SLC22A16
Ensembl
ENSG00000004809
Chromosome
6
Canonical length
577 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

577 residues, UniProt reviewed canonical sequence.

>Q86VW1|SLC22A16
     1  MGSRHFEGIY DHVGHFGRFQ RVLYFICAFQ NISCGIHYLA SVFMGVTPHH VCRPPGNVSQ
    61  VVFHNHSNWS LEDTGALLSS GQKDYVTVQL QNGEIWELSR CSRNKRENTS SLGYEYTGSK
   121  KEFPCVDGYI YDQNTWKSTA VTQWNLVCDR KWLAMLIQPL FMFGVLLGSV TFGYFSDRLG
   181  RRVVLWATSS SMFLFGIAAA FAVDYYTFMA ARFFLAMVAS GYLVVGFVYV MEFIGMKSRT
   241  WASVHLHSFF AVGTLLVALT GYLVRTWWLY QMILSTVTVP FILCCWVLPE TPFWLLSEGR
   301  YEEAQKIVDI MAKWNRASSC KLSELLSLDL QGPVSNSPTE VQKHNLSYLF YNWSITKRTL
   361  TVWLIWFTGS LGFYSFSLNS VNLGGNEYLN LFLLGVVEIP AYTFVCIAMD KVGRRTVLAY
   421  SLFCSALACG VVMVIPQKHY ILGVVTAMVG KFAIGAAFGL IYLYTAELYP TIVRSLAVGS
   481  GSMVCRLASI LAPFSVDLSS IWIFIPQLFV GTMALLSGVL TLKLPETLGK RLATTWEEAA
   541  KLESENESKS SKLLLTTNNS GLEKTEAITP RDSGLGE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC22A16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • testis: 20 nTPM
  • bone marrow: 19 nTPM
  • parathyroid gland: 3.5 nTPM
  • smooth muscle: 1.6 nTPM
  • thymus: 1.1 nTPM
  • endometrium: 0.7 nTPM

Single-cell type

  • erythrocyte progenitors: 120 nCPM
  • late primary spermatocytes: 113 nCPM
  • hematopoietic stem cells: 50 nCPM
  • late spermatids: 46 nCPM
  • neutrophil progenitors: 45 nCPM
  • early spermatids: 36 nCPM

Immune cell

  • classical monocyte: 7 nTPM
  • basophil: 5.8 nTPM
  • myeloid DC: 4 nTPM
  • intermediate monocyte: 1.5 nTPM
  • total PBMC: 1.5 nTPM
  • eosinophil: 1.3 nTPM

Brain region

  • white matter: 0.7 nTPM
  • medulla oblongata: 0.5 nTPM
  • basal ganglia: 0.3 nTPM
  • cerebral cortex: 0.3 nTPM
  • midbrain: 0.3 nTPM
  • pons: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.85
gnomAD pLI
0
gnomAD missense Z
-0.64
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC22A16 as an antibody target. Whether an autoantibody or antibody against SLC22A16 could matter depends on whether native SLC22A16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC22A16 is annotated at the cell surface, where native SLC22A16 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC22A16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC22A16. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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