SLC22A15
Solute carrier family 22 member 15
Also known as: FLIPT1, S22AF_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IZD6
- Gene
- SLC22A15
- Ensembl
- ENSG00000163393
- Chromosome
- 1
- Canonical length
- 547 aa
- Protein class
- Metabolic proteins, Predicted membrane proteins, Transporters
OverviewNCBI Gene
Organic ion transporters, such as SLC22A15, transport various medically and physiologically important compounds, including pharmaceuticals, toxins, hormones, neurotransmitters, and cellular metabolites. These transporters are also referred to as amphiphilic solute facilitators (ASFs).[supplied by OMIM, Apr 2004]
Canonical amino-acid sequenceUniProt
547 residues, UniProt reviewed canonical sequence.
>Q8IZD6|SLC22A15
1 MEVEEAFQAV GEMGIYQMYL CFLLAVLLQL YVATEAILIA LVGATPSYHW DLAELLPNQS
61 HGNQSAGEDQ AFGDWLLTAN GSEIHKHVHF SSSFTSIASE WFLIANRSYK VSAASSFFFS
121 GVFVGVISFG QLSDRFGRKK VYLTGFALDI LFAIANGFSP SYEFFAVTRF LVGMMNGGMS
181 LVAFVLLNEC VGTAYWALAG SIGGLFFAVG IAQYALLGYF IRSWRTLAIL VNLQGTVVFL
241 LSLFIPESPR WLYSQGRLSE AEEALYLIAK RNRKLKCTFS LTHPANRSCR ETGSFLDLFR
301 YRVLLGHTLI LMFIWFVCSL VYYGLTLSAG DLGGSIYANL ALSGLIEIPS YPLCIYLINQ
361 KWFGRKRTLS AFLCLGGLAC LIVMFLPEKK DTGVFAVVNS HSLSLLGKLT ISAAFNIVYI
421 YTSELYPTVI RNVGLGTCSM FSRVGGIIAP FIPSLKYVQW SLPFIVFGAT GLTSGLLSLL
481 LPETLNSPLL ETFSDLQVYS YRRLGEEALS LQALDPQQCV DKESSLGSES EEEEEFYDAD
541 EETQMIKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SLC22A15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 12
- Mean surface accessibility (rSASA)
- 0.27
- Highest tissue expression
- 29 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 29 nTPM
- spinal cord: 13 nTPM
- skin: 8.9 nTPM
- midbrain: 8.7 nTPM
- hippocampal formation: 8.3 nTPM
- hypothalamus: 6.6 nTPM
Single-cell type
- neutrophil progenitors: 654 nCPM
- neutrophils: 630 nCPM
- oligodendrocytes: 356 nCPM
- monocyte progenitors: 203 nCPM
- ependymal cells: 195 nCPM
- distal convoluted tubule cells: 159 nCPM
Immune cell
- neutrophil: 1.3 nTPM
- non-classical monocyte: 1.2 nTPM
- classical monocyte: 0.8 nTPM
- basophil: 0.3 nTPM
- eosinophil: 0.3 nTPM
- intermediate monocyte: 0.2 nTPM
Brain region
- white matter: 72 nTPM
- basal ganglia: 42 nTPM
- pons: 38 nTPM
- cerebral cortex: 37 nTPM
- medulla oblongata: 36 nTPM
- thalamus: 35 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.94
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.68
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SLC22A15 as an antibody target. Whether an autoantibody or antibody against SLC22A15 could matter depends on whether native SLC22A15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SLC22A15 is annotated at the cell surface, where native SLC22A15 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label SLC22A15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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