Seroatlas · Human Serome Atlas

SLC22A13

Solute carrier family 22 member 13

Also known as: OAT10, OCTL1, OCTL3, ORCTL3, S22AD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y226
Gene
SLC22A13
Ensembl
ENSG00000172940
Chromosome
3
Canonical length
551 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

551 residues, UniProt reviewed canonical sequence.

>Q9Y226|SLC22A13
     1  MAQFVQVLAE IGDFGRFQIQ LLILLCVLNF LSPFYFFAHV FMVLDEPHHC AVAWVKNHTF
    61  NLSAAEQLVL SVPLDTAGHP EPCLMFRPPP ANASLQDILS HRFNETQPCD MGWEYPENRL
   121  PSLKNEFNLV CDRKHLKDTT QSVFMAGLLV GTLMFGPLCD RIGRKATILA QLLLFTLIGL
   181  ATAFVPSFEL YMALRFAVAT AVAGLSFSNV TLLTEWVGPS WRTQAVVLAQ CNFSLGQMVL
   241  AGLAYGFRNW RLLQITGTAP GLLLFFYFWA LPESARWLLT RGRMDEAIQL IQKAASVNRR
   301  KLSPELMNQL VPEKTGPSGN ALDLFRHPQL RKVTLIIFCV WFVDSLGYYG LSLQVGDFGL
   361  DVYLTQLIFG AVEVPARCSS IFMMQRFGRK WSQLGTLVLG GLMCIIIIFI PADLPVVVTM
   421  LAVVGKMATA AAFTISYVYS AELFPTILRQ TGMGLVGIFS RIGGILTPLV ILLGEYHAAL
   481  PMLIYGSLPI VAGLLCTLLP ETHGQGLKDT LQDLELGPHP RSPKSVPSEK ETEAKGRTSS
   541  PGVAFVSSTY F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC22A13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
8.4 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 8.4 nTPM
  • cerebellum: 0.2 nTPM
  • esophagus: 0.2 nTPM
  • testis: 0.2 nTPM
  • bone marrow: 0.1 nTPM
  • cervix: 0.1 nTPM

Single-cell type

  • neutrophils: 6.9 nCPM
  • endometrial glandular cells: 6.3 nCPM
  • endometrial luminal cells: 6.1 nCPM
  • retinal horizontal cells: 6 nCPM
  • cdc: 5.5 nCPM
  • respiratory ionocytes: 5.1 nCPM

Immune cell

  • T-reg: 0.8 nTPM
  • classical monocyte: 0.1 nTPM
  • MAIT T-cell: 0.1 nTPM
  • memory B-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM

Brain region

  • cerebral cortex: 5.1 nTPM
  • cerebellum: 4.3 nTPM
  • white matter: 3.9 nTPM
  • amygdala: 3.1 nTPM
  • basal ganglia: 3.1 nTPM
  • hippocampal formation: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.38
gnomAD pLI
0
gnomAD missense Z
0.11
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC22A13 as an antibody target. Whether an autoantibody or antibody against SLC22A13 could matter depends on whether native SLC22A13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC22A13 is annotated at the cell surface, where native SLC22A13 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC22A13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC22A13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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