Seroatlas · Human Serome Atlas

SLC22A11

Solute carrier family 22 member 11

Also known as: OAT4, S22AB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NSA0
Gene
SLC22A11
Ensembl
ENSG00000168065
Chromosome
11
Canonical length
550 aa
Protein class
FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Canonical amino-acid sequenceUniProt

550 residues, UniProt reviewed canonical sequence.

>Q9NSA0|SLC22A11
     1  MAFSKLLEQA GGVGLFQTLQ VLTFILPCLM IPSQMLLENF SAAIPGHRCW THMLDNGSAV
    61  STNMTPKALL TISIPPGPNQ GPHQCRRFRQ PQWQLLDPNA TATSWSEADT EPCVDGWVYD
   121  RSVFTSTIVA KWDLVCSSQG LKPLSQSIFM SGILVGSFIW GLLSYRFGRK PMLSWCCLQL
   181  AVAGTSTIFA PTFVIYCGLR FVAAFGMAGI FLSSLTLMVE WTTTSRRAVT MTVVGCAFSA
   241  GQAALGGLAF ALRDWRTLQL AASVPFFAIS LISWWLPESA RWLIIKGKPD QALQELRKVA
   301  RINGHKEAKN LTIEVLMSSV KEEVASAKEP RSVLDLFCVP VLRWRSCAML VVNFSLLISY
   361  YGLVFDLQSL GRDIFLLQAL FGAVDFLGRA TTALLLSFLG RRTIQAGSQA MAGLAILANM
   421  LVPQDLQTLR VVFAVLGKGC FGISLTCLTI YKAELFPTPV RMTADGILHT VGRLGAMMGP
   481  LILMSRQALP LLPPLLYGVI SIASSLVVLF FLPETQGLPL PDTIQDLESQ KSTAAQGNRQ
   541  EAVTVESTSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC22A11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 36 nTPM
  • placenta: 31 nTPM
  • epididymis: 10 nTPM
  • liver: 0.3 nTPM
  • adrenal gland: 0.1 nTPM
  • choroid plexus: 0.1 nTPM

Single-cell type

  • syncytiotrophoblasts: 2,300 nCPM
  • cytotrophoblasts: 836 nCPM
  • migrating cytotrophoblasts: 368 nCPM
  • epididymal principal cells: 101 nCPM
  • proximal tubule cells: 85 nCPM
  • epididymal efferent duct absorptive cells: 44 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 0.2 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • choroid plexus: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.02
gnomAD pLI
0
gnomAD missense Z
0.24
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC22A11 as an antibody target. Whether an autoantibody or antibody against SLC22A11 could matter depends on whether native SLC22A11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC22A11 is annotated at the cell surface, where native SLC22A11 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC22A11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC22A11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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