Seroatlas · Human Serome Atlas

SLC22A10

Solute carrier family 22 member 10

Also known as: hOAT5, OAT5, S22AA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q63ZE4
Gene: SLC22A10
Ensembl: ENSG00000184999
Chromosome: 11
Canonical length: 541 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

541 residues, UniProt reviewed canonical sequence.

>Q63ZE4|SLC22A10
     1  MAFEELLSQV GGLGRFQMLH LVFILPSLML LIPHILLENF AAAIPGHRCW VHMLDNNTGS
    61  GNETGILSED ALLRISIPLD SNLRPEKCRR FVHPQWQLLH LNGTIHSTSE ADTEPCVDGW
   121  VYDQSYFPST IVTKWDLVCD YQSLKSVVQF LLLTGMLVGG IIGGHVSDRF GRRFILRWCL
   181  LQLAITDTCA AFAPTFPVYC VLRFLAGFSS MIIISNNSLP ITEWIRPNSK ALVVILSSGA
   241  LSIGQIILGG LAYVFRDWQT LHVVASVPFF VFFLLSRWLV ESARWLIITN KLDEGLKALR
   301  KVARTNGIKN AEETLNIEVV RSTMQEELDA AQTKTTVCDL FRNPSMRKRI CILVFLRFAN
   361  TIPFYGTMVN LQHVGSNIFL LQVLYGAVAL IVRCLALLTL NHMGRRISQI LFMFLVGLSI
   421  LANTFVPKEM QTLRVALACL GIGCSAATFS SVAVHFIELI PTVLRARASG IDLTASRIGA
   481  ALAPLLMTLT VFFTTLPWII YGIFPIIGGL IVFLLPETKN LPLPDTIKDV ENQKKNLKEK
   541  A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC22A10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 11
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 95 nTPM

Expression across tissuesHPA

Tissue

liver: 95 nTPM
salivary gland: 0.3 nTPM
bone marrow: 0.2 nTPM
choroid plexus: 0.2 nTPM
epididymis: 0.2 nTPM
skin: 0.2 nTPM

Single-cell type

brain excitatory neurons: 70 nCPM
hepatocytes: 35 nCPM
proximal tubule cells: 24 nCPM
brain inhibitory neurons: 20 nCPM
adipocytes: 8.2 nCPM
choroid plexus epithelial cells: 7 nCPM

Immune cell

neutrophil: 0.6 nTPM
basophil: 0.3 nTPM
naive B-cell: 0.3 nTPM
NK-cell: 0.3 nTPM
gdT-cell: 0.2 nTPM
memory B-cell: 0.2 nTPM

Brain region

cerebral cortex: 7 nTPM
amygdala: 3.6 nTPM
white matter: 3.6 nTPM
basal ganglia: 3.3 nTPM
hypothalamus: 2.2 nTPM
hippocampal formation: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: -0.83
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC22A10 as an antibody target. Whether an autoantibody or antibody against SLC22A10 could matter depends on whether native SLC22A10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC22A10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC22A10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...