Seroatlas · Human Serome Atlas

SLC18B1

MFS-type transporter SLC18B1

Also known as: C6orf192, dJ55C23.6, S18B1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NT16
Gene: SLC18B1
Ensembl: ENSG00000146409
Chromosome: 6
Canonical length: 456 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene encodes a protein, which has high sequence similarity to rat, xenopus and zebrafish proteins. The protein function is unknown. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

456 residues, UniProt reviewed canonical sequence.

>Q6NT16|SLC18B1
     1  MEALGDLEGP RAPGGDDPAG SAGETPGWLS REQVFVLISA ASVNLGSMMC YSILGPFFPK
    61  EAEKKGASNT IIGMIFGCFA LFELLASLVF GNYLVHIGAK FMFVAGMFVS GGVTILFGVL
   121  DRVPDGPVFI AMCFLVRVMD AVSFAAAMTA SSSILAKAFP NNVATVLGSL ETFSGLGLIL
   181  GPPVGGFLYQ SFGYEVPFIV LGCVVLLMVP LNMYILPNYE SDPGEHSFWK LIALPKVGLI
   241  AFVINSLSSC FGFLDPTLSL FVLEKFNLPA GYVGLVFLGM ALSYAISSPL FGLLSDKRPP
   301  LRKWLLVFGN LITAGCYMLL GPVPILHIKS QLWLLVLILV VSGLSAGMSI IPTFPEILSC
   361  AHENGFEEGL STLGLVSGLF SAMWSIGAFM GPTLGGFLYE KIGFEWAAAI QGLWALISGL
   421  AMGLFYLLEY SRRKRSKSQN ILSTEEERTT LLPNET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC18B1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 28 nTPM
amygdala: 28 nTPM
choroid plexus: 24 nTPM
basal ganglia: 23 nTPM
midbrain: 21 nTPM
hippocampal formation: 20 nTPM

Single-cell type

bergmann glia: 167 nCPM
hofbauer cells: 158 nCPM
astrocytes: 143 nCPM
choroid plexus epithelial cells: 125 nCPM
ependymal cells: 100 nCPM
oligodendrocyte progenitor cells: 78 nCPM

Immune cell

myeloid DC: 20 nTPM
plasmacytoid DC: 16 nTPM
classical monocyte: 15 nTPM
T-reg: 12 nTPM
naive B-cell: 9.8 nTPM
naive CD4 T-cell: 9.5 nTPM

Brain region

thalamus: 28 nTPM
choroid plexus: 24 nTPM
spinal cord: 23 nTPM
white matter: 22 nTPM
midbrain: 22 nTPM
cerebellum: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0
gnomAD missense Z: -0.38
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC18B1 as an antibody target. Whether an autoantibody or antibody against SLC18B1 could matter depends on whether native SLC18B1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC18B1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC18B1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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