Seroatlas · Human Serome Atlas

SLC18A2

Synaptic vesicular amine transporter

Also known as: SVAT, SVMT, VMAT2, VMAT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q05940
Gene
SLC18A2
Ensembl
ENSG00000165646
Chromosome
10
Canonical length
514 aa
Protein class
Disease related genes, FDA approved drug targets, Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Vesicles,Centrosome

OverviewNCBI Gene

This gene encodes an transmembrane protein that functions as an ATP-dependent transporter of monoamines, such as dopamine, norepinephrine, serotonin, and histamine. This protein transports amine neurotransmitters into synaptic vesicles. Polymorphisms in this gene may be associated with schizophrenia, bipolar disorder, and other neurological/psychiatric ailments. [provided by RefSeq, Jun 2018]

Canonical amino-acid sequenceUniProt

514 residues, UniProt reviewed canonical sequence.

>Q05940|SLC18A2
     1  MALSELALVR WLQESRRSRK LILFIVFLAL LLDNMLLTVV VPIIPSYLYS IKHEKNATEI
    61  QTARPVHTAS ISDSFQSIFS YYDNSTMVTG NATRDLTLHQ TATQHMVTNA SAVPSDCPSE
   121  DKDLLNENVQ VGLLFASKAT VQLITNPFIG LLTNRIGYPI PIFAGFCIMF VSTIMFAFSS
   181  SYAFLLIARS LQGIGSSCSS VAGMGMLASV YTDDEERGNV MGIALGGLAM GVLVGPPFGS
   241  VLYEFVGKTA PFLVLAALVL LDGAIQLFVL QPSRVQPESQ KGTPLTTLLK DPYILIAAGS
   301  ICFANMGIAM LEPALPIWMM ETMCSRKWQL GVAFLPASIS YLIGTNIFGI LAHKMGRWLC
   361  ALLGMIIVGV SILCIPFAKN IYGLIAPNFG VGFAIGMVDS SMMPIMGYLV DLRHVSVYGS
   421  VYAIADVAFC MGYAIGPSAG GAIAKAIGFP WLMTIIGIID ILFAPLCFFL RSPPAKEEKM
   481  AILMDHNCPI KTKMYTQNNI QSYPIGEDEE SESD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC18A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • midbrain: 36 nTPM
  • cervix: 28 nTPM
  • adrenal gland: 14 nTPM
  • ovary: 12 nTPM
  • hypothalamus: 10 nTPM
  • prostate: 8.6 nTPM

Single-cell type

  • mast cells: 648 nCPM
  • endometrial glandular cells: 307 nCPM
  • adrenal medulla cells: 138 nCPM
  • platelets: 88 nCPM
  • neuroendocrine cells: 79 nCPM
  • other brain neurons: 67 nCPM

Immune cell

  • basophil: 60 nTPM
  • plasmacytoid DC: 3.8 nTPM
  • total PBMC: 2 nTPM
  • eosinophil: 0.8 nTPM
  • naive CD8 T-cell: 0.6 nTPM
  • neutrophil: 0.3 nTPM

Brain region

  • midbrain: 173 nTPM
  • pons: 150 nTPM
  • hypothalamus: 48 nTPM
  • thalamus: 11 nTPM
  • medulla oblongata: 8.8 nTPM
  • basal ganglia: 3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC18A2.

Disease | AllUniProt

Conditions SLC18A2 is implicated in, by any mechanism.

  • Parkinsonism-dystonia 2, infantile-onset (PKDYS2) MIM:618049

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 255 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.08
gnomAD missense Z
1.25
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC18A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC18A2 as an antibody target. Whether an autoantibody or antibody against SLC18A2 could matter depends on whether native SLC18A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC18A2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC18A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC18A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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