Seroatlas · Human Serome Atlas

SLC15A5

Solute carrier family 15 member 5

Also known as: S15A5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NIM6
Gene: SLC15A5
Ensembl: ENSG00000188991
Chromosome: 12
Canonical length: 579 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

579 residues, UniProt reviewed canonical sequence.

>A6NIM6|SLC15A5
     1  MSVTGFTITD EKVHLYHSIE KEKTVRHIGD LCSSHSVKKI QVGICLLLVE LCERFTFFEV
    61  VCNMIPFCTI KLGYHNCQAA ILNLCFIGTS ILTPVFVRWL TDVYLGRNKL VYICLFLHFL
   121  GTALLSVVAF PLEDFYLGTY HAVNNIPKTE QHRLFYVALL TICLGIGGVR AIVCPLGAFG
   181  LQEYGSQKTM SFFNWFYWLM NLNATIVFLG ISYIQHSQAW ALVLLIPFMS MLMAVITLHM
   241  IYYNLIYQSE KRCSLLTGVG VLVSALKTCH PQYCHLGRDV TSQLDHAKEK NGGCYSELHV
   301  EDTTFFLTLL PLFIFQLLYR MCIMQIPSGY YLQTMNSNLN LDGFLLPIAV MNAISSLPLL
   361  ILAPFLEYFS TCLFPSKRVG SFLSTCIIAG NLFAALSVMI AGFFEIHRKH FPAVEQPLSG
   421  KVLTVSSMPC FYLILQYVLL GVAETLVNPA LSVISYRFVP SNVRGTSMNF LTLFNGFGCF
   481  TGALLVKLVY LISDGNWFPN TLNKGNLESF FFFLASLTLL NVLGFCSVSQ RYCNLNHFNA
   541  QNIRGSNLEE TLLLHEKSLK FYGSIQEFSS SIDLWETAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC15A5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 11
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0.2 nTPM
midbrain: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
breast: 0.1 nTPM
cerebral cortex: 0.1 nTPM

Single-cell type

adipocytes: 58 nCPM
cardiomyocytes: 17 nCPM
undifferentiated spermatogonia: 14 nCPM
bergmann glia: 11 nCPM
rod photoreceptor cells: 7.3 nCPM
astrocytes: 7.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1 nTPM
basal ganglia: 0.8 nTPM
hippocampal formation: 0.7 nTPM
hypothalamus: 0.5 nTPM
midbrain: 0.5 nTPM
pons: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: 0.91

OntologyGO

Biological processes

Molecular functions

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC15A5 as an antibody target. Whether an autoantibody or antibody against SLC15A5 could matter depends on whether native SLC15A5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC15A5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC15A5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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