Seroatlas · Human Serome Atlas

SLC15A3

Solute carrier family 15 member 3

Also known as: hPTR3, PHT2, S15A3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IY34
Gene: SLC15A3
Ensembl: ENSG00000110446
Chromosome: 11
Canonical length: 581 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location: Vesicles
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables dipeptide transmembrane transporter activity. Involved in dipeptide import across plasma membrane. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

581 residues, UniProt reviewed canonical sequence.

>Q8IY34|SLC15A3
     1  MPAPRAREQP RVPGERQPLL PRGARGPRRW RRAAGAAVLL VEMLERAAFF GVTANLVLYL
    61  NSTNFNWTGE QATRAALVFL GASYLLAPVG GWLADVYLGR YRAVALSLLL YLAASGLLPA
   121  TAFPDGRSSF CGEMPASPLG PACPSAGCPR SSPSPYCAPV LYAGLLLLGL AASSVRSNLT
   181  SFGADQVMDL GRDATRRFFN WFYWSINLGA VLSLLVVAFI QQNISFLLGY SIPVGCVGLA
   241  FFIFLFATPV FITKPPMGSQ VSSMLKLALQ NCCPQLWQRH SARDRQCARV LADERSPQPG
   301  ASPQEDIANF QVLVKILPVM VTLVPYWMVY FQMQSTYVLQ GLHLHIPNIF PANPANISVA
   361  LRAQGSSYTI PEAWLLLANV VVVLILVPLK DRLIDPLLLR CKLLPSALQK MALGMFFGFT
   421  SVIVAGVLEM ERLHYIHHNE TVSQQIGEVL YNAAPLSIWW QIPQYLLIGI SEIFASIPGL
   481  EFAYSEAPRS MQGAIMGIFF CLSGVGSLLG SSLVALLSLP GGWLHCPKDF GNINNCRMDL
   541  YFFLLAGIQA VTALLFVWIA GRYERASQGP ASHSRFSRDR G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC15A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

spleen: 47 nTPM
lung: 43 nTPM
lymph node: 38 nTPM
bone marrow: 33 nTPM
appendix: 29 nTPM
placenta: 26 nTPM

Single-cell type

neutrophils: 238 nCPM
müller glia: 205 nCPM
schwann cells: 142 nCPM
monocytes: 125 nCPM
hofbauer cells: 117 nCPM
kupffer cells: 88 nCPM

Immune cell

neutrophil: 13 nTPM
intermediate monocyte: 13 nTPM
plasmacytoid DC: 11 nTPM
classical monocyte: 9 nTPM
myeloid DC: 6.5 nTPM
non-classical monocyte: 6.4 nTPM

Brain region

white matter: 19 nTPM
medulla oblongata: 17 nTPM
thalamus: 17 nTPM
spinal cord: 16 nTPM
hypothalamus: 15 nTPM
choroid plexus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: 1.17
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC15A3 as an antibody target. Whether an autoantibody or antibody against SLC15A3 could matter depends on whether native SLC15A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC15A3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC15A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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