Seroatlas · Human Serome Atlas

SLC12A7

Solute carrier family 12 member 7

Also known as: DKFZP434F076, KCC4, S12A7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y666
Gene: SLC12A7
Ensembl: ENSG00000113504
Chromosome: 5
Canonical length: 1083 aa
Protein class: Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters
Subcellular location: Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables protein kinase binding activity. Predicted to be involved in several processes, including chloride ion homeostasis; monoatomic ion transmembrane transport; and potassium ion homeostasis. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1083 residues, UniProt reviewed canonical sequence.

>Q9Y666|SLC12A7
     1  MPTNFTVVPV EAHADGGGDE TAERTEAPGT PEGPEPERPS PGDGNPRENS PFLNNVEVEQ
    61  ESFFEGKNMA LFEEEMDSNP MVSSLLNKLA NYTNLSQGVV EHEEDEESRR REAKAPRMGT
   121  FIGVYLPCLQ NILGVILFLR LTWIVGVAGV LESFLIVAMC CTCTMLTAIS MSAIATNGVV
   181  PAGGSYYMIS RSLGPEFGGA VGLCFYLGTT FAGAMYILGT IEIFLTYISP GAAIFQAEAA
   241  GGEAAAMLHN MRVYGTCTLV LMALVVFVGV KYVNKLALVF LACVVLSILA IYAGVIKSAF
   301  DPPDIPVCLL GNRTLSRRSF DACVKAYGIH NNSATSALWG LFCNGSQPSA ACDEYFIQNN
   361  VTEIQGIPGA ASGVFLENLW STYAHAGAFV EKKGVPSVPV AEESRASALP YVLTDIAASF
   421  TLLVGIYFPS VTGIMAGSNR SGDLKDAQKS IPTGTILAIV TTSFIYLSCI VLFGACIEGV
   481  VLRDKFGEAL QGNLVIGMLA WPSPWVIVIG SFFSTCGAGL QSLTGAPRLL QAIARDGIVP
   541  FLQVFGHGKA NGEPTWALLL TVLICETGIL IASLDSVAPI LSMFFLMCYL FVNLACAVQT
   601  LLRTPNWRPR FKFYHWTLSF LGMSLCLALM FICSWYYALS AMLIAGCIYK YIEYRGAEKE
   661  WGDGIRGLSL NAARYALLRV EHGPPHTKNW RPQVLVMLNL DAEQAVKHPR LLSFTSQLKA
   721  GKGLTIVGSV LEGTYLDKHM EAQRAEENIR SLMSTEKTKG FCQLVVSSSL RDGMSHLIQS
   781  AGLGGLKHNT VLMAWPASWK QEDNPFSWKN FVDTVRDTTA AHQALLVAKN VDSFPQNQER
   841  FGGGHIDVWW IVHDGGMLML LPFLLRQHKV WRKCRMRIFT VAQVDDNSIQ MKKDLQMFLY
   901  HLRISAEVEV VEMVENDISA FTYERTLMME QRSQMLKQMQ LSKNEQEREA QLIHDRNTAS
   961  HTAAAARTQA PPTPDKVQMT WTREKLIAEK YRSRDTSLSG FKDLFSMKPD QSNVRRMHTA
  1021  VKLNGVVLNK SQDAQLVLLN MPGPPKNRQG DENYMEFLEV LTEGLNRVLL VRGGGREVIT
  1081  IYS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC12A7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 72 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 72 nTPM
liver: 69 nTPM
kidney: 42 nTPM
spleen: 33 nTPM
small intestine: 30 nTPM
testis: 29 nTPM

Single-cell type

proximal tubule cells: 75 nCPM
ependymal cells: 44 nCPM
renal collecting duct principal cells: 44 nCPM
renal collecting duct intercalated cells: 32 nCPM
cardiomyocytes: 27 nCPM
microglia: 27 nCPM

Immune cell

non-classical monocyte: 3.8 nTPM
intermediate monocyte: 2.7 nTPM
myeloid DC: 2.1 nTPM
classical monocyte: 1.8 nTPM
NK-cell: 1.4 nTPM
memory CD8 T-cell: 1.3 nTPM

Brain region

choroid plexus: 19 nTPM
hypothalamus: 18 nTPM
midbrain: 16 nTPM
thalamus: 13 nTPM
cerebral cortex: 12 nTPM
amygdala: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: 1.32
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC12A7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

LGALS3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC12A7 as an antibody target. Whether an autoantibody or antibody against SLC12A7 could matter depends on whether native SLC12A7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC12A7 is annotated at the cell surface, where native SLC12A7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC12A7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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