Seroatlas · Human Serome Atlas

SLC10A7

Sodium/bile acid cotransporter 7

Also known as: C4orf13, DKFZp313H0531, DKFZp566M114, DKFZp779O2438, MGC25043, NTCP7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q0GE19
Gene
SLC10A7
Ensembl
ENSG00000120519
Chromosome
4
Canonical length
340 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to enable symporter activity. Involved in bone development; heparin proteoglycan biosynthetic process; and intracellular calcium ion homeostasis. Located in Golgi apparatus; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>Q0GE19|SLC10A7
     1  MRLLERMRKD WFMVGIVLAI AGAKLEPSIG VNGGPLKPEI TVSYIAVATI FFNSGLSLKT
    61  EELTSALVHL KLHLFIQIFT LAFFPATIWL FLQLLSITPI NEWLLKGLQT VGCMPPPVSS
   121  AVILTKAVGG NEAAAIFNSA FGSFLGIVIT PLLLLLFLGS SSSVPFTSIF SQLFMTVVVP
   181  LIIGQIVRRY IKDWLERKKP PFGAISSSVL LMIIYTTFCD TFSNPNIDLD KFSLVLILFI
   241  IFSIQLSFML LTFIFSTRNN SGFTPADTVA IIFCSTHKSL TLGIPMLKIV FAGHEHLSLI
   301  SVPLLIYHPA QILLGSVLVP TIKSWMVSRQ KGVKLTRPTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC10A7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
10
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 12 nTPM
  • stomach: 9.3 nTPM
  • rectum: 8.7 nTPM
  • placenta: 8.3 nTPM
  • cervix: 6.8 nTPM
  • colon: 6.5 nTPM

Single-cell type

  • mast cells: 159 nCPM
  • somatotrophs: 148 nCPM
  • prostatic glandular cells: 125 nCPM
  • innate lymphoid cells: 122 nCPM
  • neutrophil progenitors: 119 nCPM
  • plasma cells: 119 nCPM

Immune cell

  • basophil: 11 nTPM
  • T-reg: 5.1 nTPM
  • NK-cell: 5 nTPM
  • intermediate monocyte: 4.8 nTPM
  • eosinophil: 4.5 nTPM
  • myeloid DC: 4 nTPM

Brain region

  • medulla oblongata: 13 nTPM
  • white matter: 13 nTPM
  • basal ganglia: 11 nTPM
  • spinal cord: 11 nTPM
  • hypothalamus: 11 nTPM
  • pons: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC10A7.

Disease | AllUniProt

Conditions SLC10A7 is implicated in, by any mechanism.

  • Short stature, amelogenesis imperfecta, and skeletal dysplasia with scoliosis (SSASKS) MIM:618363

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 91 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Short stature, amelogenesis imperfecta, and skeletal dysplasia with scoliosis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1
gnomAD pLI
0
gnomAD missense Z
1.34
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC10A7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC10A7 as an antibody target. Whether an autoantibody or antibody against SLC10A7 could matter depends on whether native SLC10A7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC10A7 is annotated at the cell surface, where native SLC10A7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC10A7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC10A7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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