Seroatlas · Human Serome Atlas

DPY19L4

Probable C-mannosyltransferase DPY19L4

Also known as: D19L4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z388
Gene: DPY19L4
Ensembl: ENSG00000156162
Chromosome: 8
Canonical length: 723 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable mannosyltransferase activity. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

723 residues, UniProt reviewed canonical sequence.

>Q7Z388|DPY19L4
     1  MAEEEGPPVE LRQRKKPKSS ENKESAKEEK ISDIPIPERA PKHVLFQRFA KIFIGCLAAV
    61  TSGMMYALYL SAYHERKFWF SNRQELEREI TFQGDSAIYY SYYKDMLKAP SFERGVYELT
   121  HNNKTVSLKT INAVQQMSLY PELIASILYQ ATGSNEIIEP VYFYIGIVFG LQGIYVTALF
   181  VTSWLMSGTW LAGMLTVAWF VINRVDTTRI EYSIPLRENW ALPYFACQIA ALTGYLKSNL
   241  NTYGERFCYL LMSASTYTFM MMWEYSHYLL FLQAISLFLL DTFSVEQSDK VYEVYKIYIF
   301  SLFLGYLLQF ENPALLVSPL LSLVAALMLA KCLQLNVKKG SFVAKIIKVI NFYLVCTLTI
   361  TLNIIMKMFV PHKENGHMLK FLEVKFGLNM TKNFTMNWLL CQESLQAPSQ DFFLRLTQSS
   421  LLPFYILVLI ICFLSMLQVI FRRINGKSLK ETVTLEDGRI GERPEIIYHV IHTILLGSLA
   481  MVIEGLKYIW IPYVCMLAAF GVCSPELWMT LFKWLRLRTV HPILLALILS MAVPTIIGLS
   541  LWKEFFPRLM TELMELQEFY DPDTVELMTW IKRQAPVAAV FAGSPQLMGA IKLCTGWMVT
   601  SLPLYNDDDL LKRNENIYQI YSKRSAEDIY KILTSYKANY LIVEDAICNE VGPMRGCRVK
   661  DLLDIANGHM VCEEGDKLTY SKYGRFCHEV KINYSPYVNY FTRVYWNRSY FVYKINTVIS
   721  FQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPY19L4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 25 nTPM
ovary: 16 nTPM
thyroid gland: 15 nTPM
liver: 15 nTPM
heart muscle: 14 nTPM
kidney: 14 nTPM

Single-cell type

sertoli cells: 131 nCPM
parietal cells: 122 nCPM
adrenal cortex cells: 69 nCPM
podocytes: 62 nCPM
retinal bipolar cells: 61 nCPM
myonuclei: 57 nCPM

Immune cell

memory CD8 T-cell: 1.6 nTPM
MAIT T-cell: 1.4 nTPM
naive CD8 T-cell: 1.4 nTPM
NK-cell: 1.4 nTPM
memory B-cell: 1.1 nTPM
naive CD4 T-cell: 1.1 nTPM

Brain region

white matter: 31 nTPM
basal ganglia: 23 nTPM
medulla oblongata: 23 nTPM
hypothalamus: 23 nTPM
cerebellum: 22 nTPM
spinal cord: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: 0.57
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

mannosyltransferase activity

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

Dpy-19/Dpy-19-like
Q-cell neuroblast polarisation
C-mannosyltransferase Dpy-19-like protein 4

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DPY19L4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SLC10A7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DPY19L4 as an antibody target. Whether an autoantibody or antibody against DPY19L4 could matter depends on whether native DPY19L4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DPY19L4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DPY19L4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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