Seroatlas · Human Serome Atlas

SIRPG

Signal-regulatory protein gamma

Also known as: bA77C3.1, CD172g, SIRP-B2, SIRPB2, SIRPG_HUMAN, SIRPgamma

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P1W8
Gene: SIRPG
Ensembl: ENSG00000089012
Chromosome: 20
Canonical length: 387 aa
Protein class: CD markers, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

387 residues, UniProt reviewed canonical sequence.

>Q9P1W8|SIRPG
     1  MPVPASWPHP PGPFLLLTLL LGLTEVAGEE ELQMIQPEKL LLVTVGKTAT LHCTVTSLLP
    61  VGPVLWFRGV GPGRELIYNQ KEGHFPRVTT VSDLTKRNNM DFSIRISSIT PADVGTYYCV
   121  KFRKGSPENV EFKSGPGTEM ALGAKPSAPV VLGPAARTTP EHTVSFTCES HGFSPRDITL
   181  KWFKNGNELS DFQTNVDPTG QSVAYSIRST ARVVLDPWDV RSQVICEVAH VTLQGDPLRG
   241  TANLSEAIRV PPTLEVTQQP MRVGNQVNVT CQVRKFYPQS LQLTWSENGN VCQRETASTL
   301  TENKDGTYNW TSWFLVNISD QRDDVVLTCQ VKHDGQLAVS KRLALEVTVH QKDQSSDATP
   361  GPASSLTALL LIAVLLGPIY VPWKQKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIRPG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

thymus: 36 nTPM
lymph node: 32 nTPM
tonsil: 26 nTPM
appendix: 12 nTPM
spleen: 8.8 nTPM
small intestine: 5.3 nTPM

Single-cell type

late primary spermatocytes: 61 nCPM
t-cells: 44 nCPM
early spermatids: 30 nCPM
late spermatids: 13 nCPM
nk-cells: 10 nCPM
melanocytes: 2.7 nCPM

Immune cell

T-reg: 370 nTPM
naive CD4 T-cell: 217 nTPM
memory CD4 T-cell: 208 nTPM
MAIT T-cell: 187 nTPM
naive CD8 T-cell: 177 nTPM
memory CD8 T-cell: 158 nTPM

Brain region

cerebral cortex: 0.5 nTPM
white matter: 0.5 nTPM
medulla oblongata: 0.4 nTPM
basal ganglia: 0.2 nTPM
pons: 0.2 nTPM
spinal cord: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0
gnomAD missense Z: -0.27
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SIRPG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CD47

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIRPG as an antibody target. Whether an autoantibody or antibody against SIRPG could matter depends on whether native SIRPG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIRPG is annotated at the cell surface, where native SIRPG is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SIRPG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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