Seroatlas · Human Serome Atlas

SIGLEC6

Sialic acid-binding Ig-like lectin 6

Also known as: CD327, CD33L, CD33L1, OB-BP1, SIGL6_HUMAN, SIGLEC-6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43699
Gene
SIGLEC6
Ensembl
ENSG00000105492
Chromosome
19
Canonical length
453 aa
Protein class
CD markers, Predicted membrane proteins, Predicted secreted proteins
Subcellular location
Plasma membrane,Cytosol
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

453 residues, UniProt reviewed canonical sequence.

>O43699|SIGLEC6
     1  MQGAQEASAS EMLPLLLPLL WAGALAQERR FQLEGPESLT VQEGLCVLVP CRLPTTLPAS
    61  YYGYGYWFLE GADVPVATND PDEEVQEETR GRFHLLWDPR RKNCSLSIRD ARRRDNAAYF
   121  FRLKSKWMKY GYTSSKLSVR VMALTHRPNI SIPGTLESGH PSNLTCSVPW VCEQGTPPIF
   181  SWMSAAPTSL GPRTTQSSVL TITPRPQDHS TNLTCQVTFP GAGVTMERTI QLNVSYAPQK
   241  VAISIFQGNS AAFKILQNTS SLPVLEGQAL RLLCDADGNP PAHLSWFQGF PALNATPISN
   301  TGVLELPQVG SAEEGDFTCR AQHPLGSLQI SLSLFVHWKP EGRAGGVLGA VWGASITTLV
   361  FLCVCFIFRV KTRRKKAAQP VQNTDDVNPV MVSGSRGHQH QFQTGIVSDH PAEAGPISED
   421  EQELHYAVLH FHKVQPQEPK VTDTEYSEIK IHK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIGLEC6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
100 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 100 nTPM
  • lung: 4.2 nTPM
  • tonsil: 4 nTPM
  • lymph node: 3.6 nTPM
  • small intestine: 3.4 nTPM
  • rectum: 2.9 nTPM

Single-cell type

  • syncytiotrophoblasts: 428 nCPM
  • migrating cytotrophoblasts: 228 nCPM
  • cytotrophoblasts: 204 nCPM
  • mast cells: 198 nCPM
  • pdcs: 16 nCPM
  • b-cells: 6.2 nCPM

Immune cell

  • plasmacytoid DC: 11 nTPM
  • memory B-cell: 7.2 nTPM
  • basophil: 4.9 nTPM
  • naive B-cell: 4.5 nTPM
  • myeloid DC: 1.7 nTPM
  • NK-cell: 0.8 nTPM

Brain region

  • white matter: 2.2 nTPM
  • basal ganglia: 2.1 nTPM
  • cerebellum: 2.1 nTPM
  • cerebral cortex: 2 nTPM
  • amygdala: 1.8 nTPM
  • choroid plexus: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0.01
gnomAD missense Z
0.24
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SIGLEC6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIGLEC6 as an antibody target. Whether an autoantibody or antibody against SIGLEC6 could matter depends on whether native SIGLEC6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIGLEC6 is annotated at the cell surface, where native SIGLEC6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SIGLEC6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SIGLEC6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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