Seroatlas · Human Serome Atlas

SHLD3

Shieldin complex subunit 3

Also known as: AC008560.1, CTC-534A2.2, FLJ26957, RINN1, SHLD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZNX1
Gene: SHLD3
Ensembl: ENSG00000253251
Chromosome: 5
Canonical length: 250 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Located in nucleolus; nucleoplasm; and site of double-strand break. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

250 residues, UniProt reviewed canonical sequence.

>Q6ZNX1|SHLD3
     1  MTTEVILHYR PCESDPTQLP KIAEKAIQDF PTRPLSRFIP WFPYDGSKLP LRPKRSPPVI
    61  SEEAAEDVKQ YLTISEHDAK SHSYDCTVDL LEFQPSLKKQ HLTWSHTLKE QTNSGNLGKQ
   121  SEKGKQHKRR SWSISLPSNN CTKNVSPLSK KLQDSLKALN LHSLYRARWT IEHTICNSQT
   181  LEDIWTKLNQ IIRHNELPSC NATIQRHLGQ IWVFCDIMYC EYVGSLLKGR LALTGKINLF
   241  VHKYGVIFSM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHLD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 17 nTPM
lymph node: 4.5 nTPM
prostate: 4.1 nTPM
breast: 4 nTPM
thymus: 3.6 nTPM
retina: 3.4 nTPM

Single-cell type

innate lymphoid cells: 0.3 nCPM
enteric stem cells: 0.2 nCPM
corticotrophs: 0.1 nCPM
erythrocyte progenitors: 0.1 nCPM
melanocytes: 0.1 nCPM
nk-cells: 0.1 nCPM

Immune cell

basophil: 16 nTPM
eosinophil: 6.4 nTPM
T-reg: 6.2 nTPM
naive CD4 T-cell: 6.1 nTPM
naive CD8 T-cell: 5.6 nTPM
NK-cell: 5 nTPM

Brain region

white matter: 6 nTPM
cerebral cortex: 5.4 nTPM
cerebellum: 5.3 nTPM
basal ganglia: 4.6 nTPM
medulla oblongata: 4.5 nTPM
spinal cord: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0.02

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Shieldin complex subunit 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SHLD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ASTE1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHLD3 as an antibody target. Whether an autoantibody or antibody against SHLD3 could matter depends on whether native SHLD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHLD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SHLD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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