Seroatlas · Human Serome Atlas

SH3TC1

SH3 domain and tetratricopeptide repeat-containing protein 1

Also known as: FLJ20356, S3TC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TE82
Gene
SH3TC1
Ensembl
ENSG00000125089
Chromosome
4
Canonical length
1336 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Nucleoli,Nucleoli rim,Cytosol

OverviewNCBI Gene

No narrative summary is available for SH3TC1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1336 residues, UniProt reviewed canonical sequence.

>Q8TE82|SH3TC1
     1  MENLPAVTTE EPTPMGRGPV GPSGGGSTRD QVRTVVMRPS VSWEKAGPEE AKAPVRGDEA
    61  PPARVAGPAA GTPPCQMGVY PTDLTLQLLA VRRKSRLRDP GLQQTLRGQL RLLENDSREM
   121  ARVLGELSAR LLSIHSDQDR IVVTFKTFEE IWKFSTYHAL GFTHHCLANL LMDQAFWLLL
   181  PSEEEETAIQ VHVDENALRL THESLLIQEG PFFVLCPDHH VRVMTGPRDA GNGPQALRQA
   241  SGAPQGEAAP ETDSSPPSPS VSSEEVAVAA APEPLIPFHQ WALRIPQDPI DDAMGGPVMP
   301  GNPLMAVGLA SALADFQGSG PEEMTFRGGD LIEILGAQVP SLPWCVGRHA ASGRVGFVRS
   361  SLISMQGPVS ELESAIFLNE EEKSFFSEGC FSEEDARQLL RRMSGTDVCS VYSLDSVEEA
   421  ETEQPQEKEI PPPCLSLEPQ ETLQKVKNVL EQCKTCPGCP QEPASWGLCA ASSDVSLQDP
   481  EEPSFCLEAE DDWEDPEALS SLLLFLNAPG YKASFRGLYD VALPWLSSVF RSFSDEEELT
   541  GRLAQARGAA KKAGLLMALA RLCFLLGRLC SRRLKLSQAR VYFEEALGAL EGSFGDLFLV
   601  VAVYANLASI YRKQKNREKC AQVVPKAMAL LLGTPDHICS TEAEGELLQL ALRRAVGGQS
   661  LQAEARACFL LARHHVHLKQ PEEALPFLER LLLLHRDSGA PEAAWLSDCY LLLADIYSRK
   721  CLPHLVLSCV KVASLRTRGS LAGSLRSVNL VLQNAPQPHS LPAQTSHYLR QALASLTPGT
   781  GQALRGPLYT SLAQLYSHHG CHGPAITFMT QAVEASAIAG VRAIVDHLVA LAWLHVLHGQ
   841  SPVALDILQS VRDAVVASED QEGVIANMVA VALKRTGRTR QAAESYYRAL RVARDLGQQR
   901  NQAVGLANFG ALCLHAGASR LAQHYLLEAV RLFSRLPLGE CGRDFTHVLL QLGHLCTRQG
   961  PAQQGKGYYE WALLVAVEMG HVESQLRAVQ RLCHFYSAVM PSEAQCVIYH ELQLSLACKV
  1021  ADKVLEGQLL ETISQLYLSL GTERAYKSAL DYTKRSLGIF IDLQKKEKEA HAWLQAGKIY
  1081  YILRQSELVD LYIQVAQNVA LYTGDPNLGL ELFEAAGDIF FDGAWEREKA VSFYRDRALP
  1141  LAVTTGNRKA ELRLCNKLVA LLATLEEPQE GLEFAHMALA LSITLGDRLN ERVAYHRLAA
  1201  LQHRLGHGEL AEHFYLKALS LCNSPLEFDE ETLYYVKVYL VLGDIIFYDL KDPFDAAGYY
  1261  QLALAAAVDL GNKKAQLKIY TRLATIYHNF LLDREKSLFF YQKARTFATE LNVRRVNLPP
  1321  LPLCGWAPWL APSHPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SH3TC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
90 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 90 nTPM
  • lymph node: 16 nTPM
  • kidney: 13 nTPM
  • spleen: 11 nTPM
  • appendix: 9 nTPM
  • adipose tissue: 7.8 nTPM

Single-cell type

  • esophageal apical cells: 150 nCPM
  • renal collecting duct intercalated cells: 120 nCPM
  • kupffer cells: 116 nCPM
  • microglia: 112 nCPM
  • macrophages: 109 nCPM
  • pdcs: 98 nCPM

Immune cell

  • plasmacytoid DC: 29 nTPM
  • non-classical monocyte: 25 nTPM
  • intermediate monocyte: 14 nTPM
  • classical monocyte: 14 nTPM
  • myeloid DC: 11 nTPM
  • naive B-cell: 8.8 nTPM

Brain region

  • white matter: 23 nTPM
  • medulla oblongata: 21 nTPM
  • spinal cord: 18 nTPM
  • pons: 17 nTPM
  • thalamus: 17 nTPM
  • cerebral cortex: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.28
gnomAD pLI
0
gnomAD missense Z
-2.15
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SH3TC1 as an antibody target. Whether an autoantibody or antibody against SH3TC1 could matter depends on whether native SH3TC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SH3TC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SH3TC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SH3TC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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