Seroatlas · Human Serome Atlas

SH3BGRL2

SH3 domain-binding glutamic acid-rich-like protein 2

Also known as: SH3L2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UJC5
Gene
SH3BGRL2
Ensembl
ENSG00000198478
Chromosome
6
Canonical length
107 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable SH3 domain binding activity. Located in nuclear membrane and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

107 residues, UniProt reviewed canonical sequence.

>Q9UJC5|SH3BGRL2
     1  MVIRVFIASS SGFVAIKKKQ QDVVRFLEAN KIEFEEVDIT MSEEQRQWMY KNVPPEKKPT
    61  QGNPLPPQIF NGDRYCGDYD SFFESKESNT VFSFLGLKPR LASKAEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SH3BGRL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
152 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 152 nTPM
  • stomach: 65 nTPM
  • thyroid gland: 55 nTPM
  • esophagus: 52 nTPM
  • liver: 50 nTPM
  • colon: 47 nTPM

Single-cell type

  • esophageal apical cells: 1,069 nCPM
  • platelets: 950 nCPM
  • salivary acinar cells: 249 nCPM
  • foveolar cells: 225 nCPM
  • lacrimal acinar cells: 223 nCPM
  • salivary duct cells: 206 nCPM

Immune cell

  • basophil: 11 nTPM
  • total PBMC: 8.7 nTPM
  • neutrophil: 2.2 nTPM
  • naive CD8 T-cell: 1 nTPM
  • eosinophil: 0.4 nTPM
  • classical monocyte: 0.2 nTPM

Brain region

  • pons: 62 nTPM
  • cerebral cortex: 60 nTPM
  • spinal cord: 56 nTPM
  • thalamus: 55 nTPM
  • white matter: 52 nTPM
  • midbrain: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.91
gnomAD pLI
0
gnomAD missense Z
0.01
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SH3BGRL2 as an antibody target. Whether an autoantibody or antibody against SH3BGRL2 could matter depends on whether native SH3BGRL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SH3BGRL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SH3BGRL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SH3BGRL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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