Seroatlas · Human Serome Atlas

SH3BGR

SH3 domain-binding glutamic acid-rich protein

Also known as: 21-GARP, SH3BG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P55822
Gene: SH3BGR
Ensembl: ENSG00000185437
Chromosome: 21
Canonical length: 239 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable SH3 domain binding activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

239 residues, UniProt reviewed canonical sequence.

>P55822|SH3BGR
     1  MPLLLLGETE PLKLERDCRS PVDPWAAASP DLALACLCHC QDLSSGAFPD RGVLGGVLFP
    61  TVEMVIKVFV ATSSGSIAIR KKQQEVVGFL EANKIDFKEL DIAGDEDNRR WMRENVPGEK
   121  KPQNGIPLPP QIFNEEQYCG DFDSFFSAKE ENIIYSFLGL APPPDSKGSE KAEEGGETEA
   181  QKEGSEDVGN LPEAQEKNEE EGETATEETE EIAMEGAEGE AEEEEETAEG EEPGEDEDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SH3BGR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 1,188 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 1,188 nTPM
tongue: 573 nTPM
heart muscle: 159 nTPM
blood vessel: 61 nTPM
midbrain: 42 nTPM
colon: 38 nTPM

Single-cell type

ependymal cells: 38 nCPM
astrocytes: 29 nCPM
oligodendrocytes: 25 nCPM
choroid plexus epithelial cells: 24 nCPM
bergmann glia: 15 nCPM
distal convoluted tubule cells: 15 nCPM

Immune cell

plasmacytoid DC: 3.8 nTPM
naive CD4 T-cell: 1.6 nTPM
memory B-cell: 1.4 nTPM
NK-cell: 1.3 nTPM
naive CD8 T-cell: 1.2 nTPM
intermediate monocyte: 0.9 nTPM

Brain region

white matter: 44 nTPM
basal ganglia: 29 nTPM
pons: 28 nTPM
medulla oblongata: 27 nTPM
hippocampal formation: 27 nTPM
hypothalamus: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0.44
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

SH3 domain binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

SH3-binding

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SH3BGR as an antibody target. Whether an autoantibody or antibody against SH3BGR could matter depends on whether native SH3BGR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SH3BGR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SH3BGR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...