Seroatlas · Human Serome Atlas

SH2D3A

SH2 domain-containing protein 3A

Also known as: NSP1, SH23A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRG2
Gene: SH2D3A
Ensembl: ENSG00000125731
Chromosome: 19
Canonical length: 576 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Microtubules,Cytokinetic bridge

OverviewNCBI Gene

Predicted to enable guanyl-nucleotide exchange factor activity and phosphotyrosine residue binding activity. Predicted to be involved in JNK cascade. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

576 residues, UniProt reviewed canonical sequence.

>Q9BRG2|SH2D3A
     1  MQVPQDGEDL AGQPWYHGLL SRQKAEALLQ QNGDFLVRAS GSRGGNPVIS CRWRGSALHF
    61  EVFRVALRPR PGRPTALFQL EDEQFPSIPA LVHSYMTGRR PLSQATGAVV SRPVTWQGPL
   121  RRSFSEDTLM DGPARIEPLR ARKWSNSQPA DLAHMGRSRE DPAGMEASTM PISALPRTSS
   181  DPVLLKAPAP LGTVADSLRA SDGQLQAKAP TKPPRTPSFE LPDASERPPT YCELVPRVPS
   241  VQGTSPSQSC PEPEAPWWEA EEDEEEENRC FTRPQAEISF CPHDAPSCLL GPQNRPLEPQ
   301  VLHTLRGLFL EHHPGSTALH LLLVDCQATG LLGVTRDQRG NMGVSSGLEL LTLPHGHHLR
   361  LELLERHQTL ALAGALAVLG CSGPLEERAA ALRGLVELAL ALRPGAAGDL PGLAAVMGAL
   421  LMPQVSRLEH TWRQLRRSHT EAALAFEQEL KPLMRALDEG AGPCDPGEVA LPHVAPMVRL
   481  LEGEEVAGPL DESCERLLRT LHGARHMVRD APKFRKVAAQ RLRGFRPNPE LREALTTGFV
   541  RRLLWGSRGA GAPRAERFEK FQRVLGVLSQ RLEPDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SH2D3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

esophagus: 31 nTPM
skin: 27 nTPM
pancreas: 19 nTPM
salivary gland: 18 nTPM
prostate: 18 nTPM
kidney: 17 nTPM

Single-cell type

esophageal apical cells: 156 nCPM
urothelial cells: 114 nCPM
extravillous trophoblasts: 86 nCPM
esophageal suprabasal cells: 72 nCPM
alveolar cells type 1: 69 nCPM
pancreatic duct cells: 68 nCPM

Immune cell

naive CD4 T-cell: 7.7 nTPM
memory CD4 T-cell: 5.9 nTPM
naive B-cell: 5.6 nTPM
memory CD8 T-cell: 5.2 nTPM
MAIT T-cell: 4.2 nTPM
naive CD8 T-cell: 4.2 nTPM

Brain region

cerebral cortex: 2.6 nTPM
choroid plexus: 2.3 nTPM
white matter: 2.3 nTPM
medulla oblongata: 2.1 nTPM
thalamus: 1.9 nTPM
pons: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: 1.05
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SH2D3A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SH2D3A as an antibody target. Whether an autoantibody or antibody against SH2D3A could matter depends on whether native SH2D3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SH2D3A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SH2D3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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