Seroatlas · Human Serome Atlas

SGPL1

Sphingosine-1-phosphate lyase 1

Also known as: SGPL1_HUMAN, SPL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95470
Gene
SGPL1
Ensembl
ENSG00000166224
Chromosome
10
Canonical length
568 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables sphinganine-1-phosphate aldolase activity. Involved in apoptotic signaling pathway; fatty acid metabolic process; and sphingolipid metabolic process. Located in endoplasmic reticulum. Implicated in nephrotic syndrome type 14. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

568 residues, UniProt reviewed canonical sequence.

>O95470|SGPL1
     1  MPSTDLLMLK AFEPYLEILE VYSTKAKNYV NGHCTKYEPW QLIAWSVVWT LLIVWGYEFV
    61  FQPESLWSRF KKKCFKLTRK MPIIGRKIQD KLNKTKDDIS KNMSFLKVDK EYVKALPSQG
   121  LSSSAVLEKL KEYSSMDAFW QEGRASGTVY SGEEKLTELL VKAYGDFAWS NPLHPDIFPG
   181  LRKIEAEIVR IACSLFNGGP DSCGCVTSGG TESILMACKA YRDLAFEKGI KTPEIVAPQS
   241  AHAAFNKAAS YFGMKIVRVP LTKMMEVDVR AMRRAISRNT AMLVCSTPQF PHGVIDPVPE
   301  VAKLAVKYKI PLHVDACLGG FLIVFMEKAG YPLEHPFDFR VKGVTSISAD THKYGYAPKG
   361  SSLVLYSDKK YRNYQFFVDT DWQGGIYASP TIAGSRPGGI SAACWAALMH FGENGYVEAT
   421  KQIIKTARFL KSELENIKGI FVFGNPQLSV IALGSRDFDI YRLSNLMTAK GWNLNQLQFP
   481  PSIHFCITLL HARKRVAIQF LKDIRESVTQ IMKNPKAKTT GMGAIYGMAQ TTVDRNMVAE
   541  LSSVFLDSLY STDTVTQGSQ MNGSPKPH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SGPL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • skin: 28 nTPM
  • esophagus: 26 nTPM
  • urinary bladder: 25 nTPM
  • small intestine: 24 nTPM
  • liver: 23 nTPM
  • parathyroid gland: 22 nTPM

Single-cell type

  • papillary tip epithelial cells: 123 nCPM
  • renal collecting duct principal cells: 90 nCPM
  • loop of henle epithelial cells: 85 nCPM
  • renal connecting tubule cells: 68 nCPM
  • renal collecting duct intercalated cells: 68 nCPM
  • distal convoluted tubule cells: 62 nCPM

Immune cell

  • non-classical monocyte: 45 nTPM
  • intermediate monocyte: 35 nTPM
  • NK-cell: 19 nTPM
  • classical monocyte: 18 nTPM
  • gdT-cell: 18 nTPM
  • MAIT T-cell: 17 nTPM

Brain region

  • medulla oblongata: 34 nTPM
  • thalamus: 33 nTPM
  • white matter: 32 nTPM
  • spinal cord: 29 nTPM
  • basal ganglia: 29 nTPM
  • midbrain: 29 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SGPL1.

Disease | AllUniProt

Conditions SGPL1 is implicated in, by any mechanism.

Disease | GeneticClinVar

29 pathogenic / likely-pathogenic of 377 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0
gnomAD missense Z
1.82
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SGPL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SGPL1 as an antibody target. Whether an autoantibody or antibody against SGPL1 could matter depends on whether native SGPL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SGPL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SGPL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SGPL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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